Molecular models of tryptophan synthase from Mycobacterium tuberculosis complexed with inhibitors

MVB Dias, F Canduri, NJF da Silveira, CM Czekster, LA Basso, MS Palma, DS Santos*, WF de Azevedo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The development of new therapies against infectious diseases is vital in developing countries. Among infectious diseases, tuberculosis is considered the leading cause of death. A target for development of new drugs is the tryptophan pathway. The last enzyme of this pathway, tryptophan synthase (TRPS), is responsible for conversion of the indole 3-glycerol phosphate into indol and the condensation of this molecule with serine-producing tryptophan. The present work describes the molecular models of TRPS from Mycobacterium tuberculosis (MtTRPS) complexed with six inhibitors, the indole 3-propanol phosphate and five arylthioalkyl-phosphonated analogs of substrate of the a-subunit. The molecular models of MtTRPS present good stereochemistry, and the binding of the inhibitors is favorable. Thus, the generated models can be used in the design of more specific drugs against tuberculosis and other infectious diseases.

Original languageEnglish
Pages (from-to)375-384
Number of pages10
JournalCell biochemistry and biophysics
Volume44
Issue number3
DOIs
Publication statusPublished - 2006
Event1st Latin-American-Protein-Society Meeting - Angra dos Reis, Brazil
Duration: 8 Nov 200412 Nov 2004

Keywords

  • tryptophan synthase
  • Mycobacterium tuberculosis
  • molecular modeling
  • drug design
  • structural bioinformatics
  • 3-DIMENSIONAL STRUCTURE
  • MULTIENZYME COMPLEX
  • PHOSPHATE

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