Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria.

AS Denes, G Jekely, PRH Steinmetz, F Raible, H Snyman, B Prud'homme, David Ellard Keith Ferrier, G Balavoine, D Arendt

Research output: Contribution to journalArticlepeer-review

308 Citations (Scopus)

Abstract

To elucidate the evolutionary origin of nervous system centralization, we investigated the molecular architecture of the trunk nervous system in the annelid Platynereis dumerilli. Annelids belong to Bilateria, an evolutionary lineage of bilateral animals that also includes vertebrates and insects. Comparing nervous system development in annelids to that of other bilaterians could provide valuable information about the common ancestor of all Bilateria. We find that the Platynereis neuroectoderm is subdivided into longitudinal progenitor domains by partially overlapping expression regions of nk and pax genes. These domains match corresponding domains in the vertebrate neural tube and give rise to conserved neural cell types. As in vertebrates, neural patterning genes are sensitive to Bmp signaling. Our data indicate that this mediolateral architecture was present in the last common bilaterian ancestor and thus support a common origin of nervous system centralization in Bilateria.

Original languageEnglish
Pages (from-to)277-288
Number of pages12
JournalCell
Volume129
Issue number2
DOIs
Publication statusPublished - 20 Apr 2007

Keywords

  • PROGENITOR-CELL IDENTITY
  • DEVELOPING SPINAL-CORD
  • MOTOR-NEURON
  • DROSOPHILA-MELANOGASTER
  • PLATYNEREIS-DUMERILII
  • INTERNEURON FATE
  • GENE
  • SPECIFICATION
  • EXPRESSION
  • PROTEINS

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