Molar efficiency

Fiona I. McGonagle; Helen F. Sneddon; Craig Jamieson; Allan Watson

doi:10.1021/sc4004532

Molar efficiency

Fiona I. McGonagle, Helen F. Sneddon, Craig Jamieson, Allan Watson

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The concept of molar efficiency is introduced as a new metric to enable assessment of reaction efficiency in discovery medicinal chemistry. Calculations from molar units enable cross-comparison of the broad range of transformations employed in discovery-phase medicinal chemistry research and is proposed to facilitate identification of more sustainable synthetic transformations.

Original language	English
Pages (from-to)	523-532
Number of pages	10
Journal	ACS Sustainable Chemistry & Engineering
Volume	2
Issue number	3
DOIs	https://doi.org/10.1021/sc4004532
Publication status	Published - 3 Mar 2014

Keywords

discovery medicinal chemistry
reaction efficiency
metrics

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10.1021/sc4004532

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title = "Molar efficiency",

abstract = "The concept of molar efficiency is introduced as a new metric to enable assessment of reaction efficiency in discovery medicinal chemistry. Calculations from molar units enable cross-comparison of the broad range of transformations employed in discovery-phase medicinal chemistry research and is proposed to facilitate identification of more sustainable synthetic transformations.",

keywords = "discovery medicinal chemistry, reaction efficiency, metrics",

author = "McGonagle, {Fiona I.} and Sneddon, {Helen F.} and Craig Jamieson and Allan Watson",

year = "2014",

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doi = "10.1021/sc4004532",

language = "English",

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journal = "ACS Sustainable Chemistry & Engineering",

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T1 - Molar efficiency

AU - McGonagle, Fiona I.

AU - Sneddon, Helen F.

AU - Jamieson, Craig

AU - Watson, Allan

PY - 2014/3/3

Y1 - 2014/3/3

N2 - The concept of molar efficiency is introduced as a new metric to enable assessment of reaction efficiency in discovery medicinal chemistry. Calculations from molar units enable cross-comparison of the broad range of transformations employed in discovery-phase medicinal chemistry research and is proposed to facilitate identification of more sustainable synthetic transformations.

AB - The concept of molar efficiency is introduced as a new metric to enable assessment of reaction efficiency in discovery medicinal chemistry. Calculations from molar units enable cross-comparison of the broad range of transformations employed in discovery-phase medicinal chemistry research and is proposed to facilitate identification of more sustainable synthetic transformations.

KW - discovery medicinal chemistry

KW - reaction efficiency

KW - metrics

U2 - 10.1021/sc4004532

DO - 10.1021/sc4004532

M3 - Article

SN - 2168-0485

VL - 2

SP - 523

EP - 532

JO - ACS Sustainable Chemistry & Engineering

JF - ACS Sustainable Chemistry & Engineering

IS - 3

ER -

Molar efficiency

Abstract

Keywords

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