Projects per year
Abstract
Image-guided photodynamic therapy has been acknowledged as one of the most demonstrative therapeutic modalities for cancer treatment because of its high precision, non-invasiveness, and improved imaging ability. A series of purely organic photosensitizers, denoted as BTMCz, BTMPTZ, and BTMPXZ, have been designed and synthesized and are found to exhibit both thermally activated delayed fluorescence and aggregation-induced emission simultaneously. Experimental and theoretical studies were combined to reveal that modulation of the donor of the photosensitizer enables distinct thermally activated delayed fluorescence via a second-order spinorbit perturbation mechanism involving lowest singlet charge-transfer and higher-lying triplet locally excited states, respectively. Further, different donor strengths and unique aggregations (H-, J- and Xtype packings) greatly influence their color-tunable up-converted luminescence and endow them with superb dispersibility in water. The confocal microscopy-based cellular uptake study confirms the successful internalization of the nano-probes. At the same time, BTMCz enables the generation of reactive oxygen species (singlet oxygen) under white-light irradiation, enabling the efficient killing of cancer cells.
Original language | English |
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Article number | 2409533 |
Journal | Small |
Volume | Online |
Early online date | 9 Jan 2025 |
DOIs | |
Publication status | E-pub ahead of print - 9 Jan 2025 |
Keywords
- Photosensitizer
- Aggregation-Induced Emission
- Thermally Activated Delayed Fluorescence
- Singlet Oxygen
- Photodynamic Therapy
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Dive into the research topics of 'Modulation of donor in purely organic triplet harvesting AIE-TADF photosensitizer for image-guided photodynamic therapy'. Together they form a unique fingerprint.-
Allan Watson Programme Grant: Boron: Beyond the Reagent
Watson, A. J. B. (PI), Morris, R. E. (CoI), Smith, A. D. (CoI) & Zysman-Colman, E. (CoI)
1/05/23 → 30/04/28
Project: Standard
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Chemistry EPSRC-JSPS: EPSRC-JSPS Core-to-Core Grant Application
Zysman-Colman, E. (PI)
1/08/18 → 31/01/24
Project: Standard
Datasets
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Modulation of Donor in Purely Organic Triplet Harvesting AIE-TADF Photosensitizer for Image-guided Photodynamic Therapy (dataset)
Barman, D. (Creator), Rajamalli, P. (Creator), Bidkar, A. P. (Creator), Sarmah, T. (Creator), Ghosh, S. S. (Creator), Zysman-Colman, E. (Creator) & Iyer, P. K. (Creator), University of St Andrews, 24 Jan 2025
DOI: 10.17630/2ee51e58-2fcc-4aa0-b51d-612aba654420
Dataset
File