Modular solid-phase synthesis, catalytic application and efficient recycling of supported phosphine-phosphite ligand libraries

Frank Heutz, Paul C J Kamer

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In spite of decades of research in the field of homogeneous asymmetric catalysis the discovery of new high performance catalysts still relies heavily on trial-and-error. There is still a lack of efficient combinatorial methods which enable the synthesis and screening of vast ligand libraries, especially for bidentate phosphorus ligands. Here we present a highly modular solid-phase synthetic approach which provides facile access to libraries of phosphine-phosphite ligands in quantitative yield requiring only minimal work-up. The obtained library of supported phosphine-phosphites was successfully applied in rhodium catalyzed asymmetric hydrogenation obtaining high enantioselectivities up to 98%. Also, these polymer supported ligands could be successfully recycled under batch conditions exhibiting only a small decline of activity and no loss of selectivity.

Original languageEnglish
Pages (from-to)2116-2123
Number of pages8
JournalDalton Transactions
Volume45
Issue number5
Early online date13 Oct 2015
DOIs
Publication statusPublished - 7 Feb 2016

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