Projects per year
Abstract
In spite of decades of research in the field of homogeneous asymmetric catalysis the discovery of new high performance catalysts still relies heavily on trial-and-error. There is still a lack of efficient combinatorial methods which enable the synthesis and screening of vast ligand libraries, especially for bidentate phosphorus ligands. Here we present a highly modular solid-phase synthetic approach which provides facile access to libraries of phosphine-phosphite ligands in quantitative yield requiring only minimal work-up. The obtained library of supported phosphine-phosphites was successfully applied in rhodium catalyzed asymmetric hydrogenation obtaining high enantioselectivities up to 98%. Also, these polymer supported ligands could be successfully recycled under batch conditions exhibiting only a small decline of activity and no loss of selectivity.
Original language | English |
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Pages (from-to) | 2116-2123 |
Number of pages | 8 |
Journal | Dalton Transactions |
Volume | 45 |
Issue number | 5 |
Early online date | 13 Oct 2015 |
DOIs | |
Publication status | Published - 7 Feb 2016 |
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Dive into the research topics of 'Modular solid-phase synthesis, catalytic application and efficient recycling of supported phosphine-phosphite ligand libraries'. Together they form a unique fingerprint.Projects
- 1 Finished
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Marie Curie SusPhos: A European Trainging Network for Sustainable Phosphorus Chemistry
Kamer, P. C. J. (PI)
1/02/13 → 31/01/16
Project: Standard