Modifiying NEMO

R T Hay

Research output: Contribution to journalEditorialpeer-review

23 Citations (Scopus)

Abstract

Genotoxic stress induces a survival response by releasing the transcription factor NF-kappaB from its inhibitor IkappaBalpha. In response to DNA damage, this initially requires the nuclear modification of the IkappaB kinase regulator NEMO/IKKgamma. by SUMO and ubiquitin.

Original languageEnglish
Pages (from-to)89-91
Number of pages4
JournalNature Cell Biology
Volume6
DOIs
Publication statusPublished - Feb 2004

Keywords

  • KAPPA-B ACTIVATION
  • ECTODERMAL DYSPLASIA
  • SUMO-1
  • UBIQUITIN
  • NUCLEAR
  • ATM

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