Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model

Nikolaos Sfakianakis, Diane Peurichard, Aaron Brunk, Christian Schmeiser

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Abstract

We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.
Original languageEnglish
Article number1811097
Number of pages14
JournalBIOMATH
Volume7
Issue number2
DOIs
Publication statusPublished - 28 Nov 2018

Keywords

  • Quantitative biology - cell behavior

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