Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model

Nikolaos Sfakianakis; Diane Peurichard; Aaron Brunk; Christian Schmeiser

doi:10.11145/j.biomath.2018.11.097

Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model

Nikolaos Sfakianakis, Diane Peurichard, Aaron Brunk, Christian Schmeiser

Applied Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.

Original language	English
Article number	1811097
Number of pages	14
Journal	BIOMATH
Volume	7
Issue number	2
DOIs	https://doi.org/10.11145/j.biomath.2018.11.097
Publication status	Published - 28 Nov 2018

Keywords

Quantitative biology - cell behavior

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11145/j.biomath.2018.11.097Licence: CC BY

Sfakianakis-2018-Modelling-cell-Biomath-1811097-CC
Copyright 2018 Sfakianakis et al. This article is distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 4.14 MBLicence: CC BY

http://adsabs.harvard.edu/abs/2018arXiv180907852S

Cite this

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abstract = "We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.",

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author = "Nikolaos Sfakianakis and Diane Peurichard and Aaron Brunk and Christian Schmeiser",

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AU - Sfakianakis, Nikolaos

AU - Peurichard, Diane

AU - Brunk, Aaron

AU - Schmeiser, Christian

N1 - Funding: N.S was partially supported by the German Science Foundation (DFG) under the grant SFB 873 “Maintenance and Differentiation of Stem Cells in Development and Disease”.

PY - 2018/11/28

Y1 - 2018/11/28

N2 - We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.

AB - We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.

KW - Quantitative biology - cell behavior

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DO - 10.11145/j.biomath.2018.11.097

M3 - Article

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JO - BIOMATH

JF - BIOMATH

IS - 2

M1 - 1811097

ER -

Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model

Abstract

Keywords

UN SDGs

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