Mixed metal-organic framework mixed-matrix membranes: insights into simultaneous moisture-triggered and catalytic delivery of nitric oxide using cryo-scanning electron microscopy

Romy Ettlinger, Simon Vornholt, Madeline Roach, Robert Tuttle, Jonathan Thai, Maadhav Kothari, Markus Boese, Andy Holwell, Morven J. Duncan, Melissa Reynolds, Russell E. Morris*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Downloads (Pure)

Abstract

The fundamental chemical and structural diversity of metal–organic frameworks (MOFs) is vast, but there is a lack of industrial adoption of these extremely versatile compounds. To bridge the gap between basic research and industry, MOF powders must be formulated into more application-relevant shapes and/or composites. Successful incorporation of varying ratios of two different MOFs, CPO-27-Ni and CuBTTri, in a thin polymer film represents an important step toward the development of mixed MOF mixed-matrix membranes. To gain insight into the distribution of the two different MOFs in the polymer, we report their investigation by Cryo-scanning electron microscopy (Cryo-SEM) tomography, which minimizes surface charging and electron beam-induced damage. Because the MOFs are based on two different metal ions, Ni and Cu, the elemental maps of the MOF composite cross sections clearly identify the size and location of each MOF in the reconstructed 3D model. The tomography run was about six times faster than conventional focused ion beam (FIB)-SEM and the first insights to image segmentation combined with machine learning could be achieved. To verify that the MOF composites combined the benefits of rapid moisture-triggered release of nitric oxide (NO) from CPO-27-Ni with the continuous catalytic generation of NO from CuBTTri, we characterized their ability to deliver NO individually and simultaneously. These MOF composites show great promise to achieve optimal dual NO delivery in real-world medical applications.
Original languageEnglish
Pages (from-to)49835-49842
Number of pages8
JournalACS Applied Materials & Interfaces
Volume15
Issue number42
Early online date11 Oct 2023
DOIs
Publication statusPublished - 25 Oct 2023

Keywords

  • Metal-organic frameworks
  • Mixed-matrix membranes
  • Composite materials
  • Nitric oxide
  • Medical applications
  • Cryo-SEM

Fingerprint

Dive into the research topics of 'Mixed metal-organic framework mixed-matrix membranes: insights into simultaneous moisture-triggered and catalytic delivery of nitric oxide using cryo-scanning electron microscopy'. Together they form a unique fingerprint.

Cite this