Microwave accelerated Suzuki coupling of chloro-aryl phosphine-oxides: A method for introducing diversity into phosphine ligands

Karen Damian, Matthew L. Clarke, Christopher J. Cobley

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

There is a demand for methodology that can rapidly produce families of catalysts for catalyst-structure-performance studies. The results reported here show microwave accelerated Suzuki coupling of a range of boronic acids with chloro-aryl phosphine-oxides can give high yields of arylated phosphine oxides. Chloro-aryl phosphine-oxide substrates have been found to be unreactive in previous studies, but in these examples, the combination of a highly active (but short lived) catalyst and instantaneous microwave heating at 140 degrees C allows the reactions to proceed. These cross-coupling reactions are being used as the basis for a rapid synthesis of phosphine ligands (readily available by microwave-assisted reduction of the phosphine oxides). (C) 2008 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalJournal of Molecular Catalysis A: Chemical
Volume284
Issue number1-2
DOIs
Publication statusPublished - 2 Apr 2008

Keywords

  • palladium
  • cross-coupling
  • microwave
  • phosphine ligands
  • diversity orientated synthesis
  • FREE HIYAMA REACTION
  • ASYMMETRIC HYDROGENATION
  • BIDENTATE LIGANDS
  • SODIUM-HYDROXIDE
  • CATALYSIS
  • COMBINATORIAL
  • LIBRARIES
  • COMPLEXES
  • DERIVATIVES
  • EFFICIENT

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