Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Marcel Schubert*, Lewis Woolfson, Isla R.M. Barnard, Andrew Morton, Becky Casement, Gavin B. Robertson, Gareth B. Miles, Samantha J. Pitt, Carl S. Tucker, Malte C. Gather

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

Original languageEnglish
Title of host publicationNovel Techniques in Microscopy - Proceedings Biophotonics Congress
Subtitle of host publicationOptics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)
PublisherOptical Society of American (OSA)
ISBN (Electronic)9781943580545
DOIs
Publication statusPublished - 8 Apr 2019
EventNovel Techniques in Microscopy, NTM 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019 - Tucson, United States
Duration: 14 Apr 201917 Apr 2019

Publication series

NameNovel Techniques in Microscopy - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)

Conference

ConferenceNovel Techniques in Microscopy, NTM 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019
Country/TerritoryUnited States
CityTucson
Period14/04/1917/04/19

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