Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Marcel Schubert; Lewis Woolfson; Isla R.M. Barnard; Andrew Morton; Becky Casement; Gavin B. Robertson; Gareth B. Miles; Samantha J. Pitt; Carl S. Tucker; Malte C. Gather

doi:10.1117/12.2526955

Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Marcel Schubert^*, Lewis Woolfson, Isla R.M. Barnard, Andrew Morton, Becky Casement, Gavin B. Robertson, Gareth B. Miles, Samantha J. Pitt, Carl S. Tucker, Malte C. Gather

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

Original language	English
Title of host publication	Novel biophotonics techniques and applications V
Editors	Arjen Amelink, Seemantini K. Nadkarni
Publisher	SPIE
Number of pages	3
ISBN (Electronic)	9781510628434
DOIs	https://doi.org/10.1117/12.2526955
Publication status	Published - 22 Jul 2019
Event	European Conferences on Biomedical Optics - Munich, Germany Duration: 23 Jun 2019 → 27 Jun 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11075
ISSN (Print)	1605-7422

Conference

Conference	European Conferences on Biomedical Optics
Country/Territory	Germany
City	Munich
Period	23/06/19 → 27/06/19

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10.1117/12.2526955

Schubert_et_al_Biophotonics_Congress_2019
Copyright © (2019) Society of Photo-Optical Instrumentation Engineers (SPIE). This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1117/12.2526955
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Schubert, M., Woolfson, L., Barnard, I. R. M., Morton, A., Casement, B., Robertson, G. B., Miles, G. B., Pitt, S. J., Tucker, C. S., & Gather, M. C. (2019). Microlaser-based contractility sensing in single cardiomyocytes and whole hearts. In A. Amelink, & S. K. Nadkarni (Eds.), Novel biophotonics techniques and applications V Article 110750C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11075). SPIE. https://doi.org/10.1117/12.2526955

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title = "Microlaser-based contractility sensing in single cardiomyocytes and whole hearts",

abstract = "Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.",

author = "Marcel Schubert and Lewis Woolfson and Barnard, {Isla R.M.} and Andrew Morton and Becky Casement and Robertson, {Gavin B.} and Miles, {Gareth B.} and Pitt, {Samantha J.} and Tucker, {Carl S.} and Gather, {Malte C.}",

year = "2019",

month = jul,

day = "22",

doi = "10.1117/12.2526955",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Arjen Amelink and Nadkarni, {Seemantini K.}",

booktitle = "Novel biophotonics techniques and applications V",

address = "United States",

note = "European Conferences on Biomedical Optics ; Conference date: 23-06-2019 Through 27-06-2019",

}

Schubert, M, Woolfson, L, Barnard, IRM, Morton, A, Casement, B, Robertson, GB, Miles, GB , Pitt, SJ, Tucker, CS & Gather, MC 2019, Microlaser-based contractility sensing in single cardiomyocytes and whole hearts. in A Amelink & SK Nadkarni (eds), Novel biophotonics techniques and applications V., 110750C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11075, SPIE, European Conferences on Biomedical Optics, Munich, Germany, 23/06/19. https://doi.org/10.1117/12.2526955

Microlaser-based contractility sensing in single cardiomyocytes and whole hearts. / Schubert, Marcel; Woolfson, Lewis; Barnard, Isla R.M. et al.
Novel biophotonics techniques and applications V. ed. / Arjen Amelink; Seemantini K. Nadkarni. SPIE, 2019. 110750C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11075).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

AU - Schubert, Marcel

AU - Woolfson, Lewis

AU - Barnard, Isla R.M.

AU - Morton, Andrew

AU - Casement, Becky

AU - Robertson, Gavin B.

AU - Miles, Gareth B.

AU - Pitt, Samantha J.

AU - Tucker, Carl S.

AU - Gather, Malte C.

PY - 2019/7/22

Y1 - 2019/7/22

N2 - Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

AB - Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

U2 - 10.1117/12.2526955

DO - 10.1117/12.2526955

M3 - Conference contribution

AN - SCOPUS:85074298611

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Novel biophotonics techniques and applications V

A2 - Amelink, Arjen

A2 - Nadkarni, Seemantini K.

PB - SPIE

T2 - European Conferences on Biomedical Optics

Y2 - 23 June 2019 through 27 June 2019

ER -

Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

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