Microfluidic Raman Spectroscopy for Bio-chemical Sensing and Analysis

Praveen Cheriyan Ashok, Kishan Dholakia

Research output: Chapter in Book/Report/Conference proceedingChapter


The detection and analysis of bio-chemical analytes are important in the fields of personal healthcare, drug development, and environmental science, among others. The field of microfluidics aims to realize portable devices which can
perform fast and sensitive bioanalyte detection with minimal sample preparation.
Raman spectroscopy is a powerful tool for analyte detection owing to its high
specificity and its ability for multi-component detection in an analyte. Combining
microfluidics with Raman spectroscopy would help achieve miniaturized analytical
devices that may provide rich information about a given analyte. However, the
low cross-section of Raman process demands special geometries to achieve
such a convergence. The majority of the previous embodiments were restricted to
free-space geometry, limiting portability. However, in recent studies, fiber-based
Raman detection system incorporated in microfluidics offers the opportunity to
develop portable optofluidic bioanalyte detection devices. Here, we review various approaches used for using Raman spectroscopy in microfluidics for analyte detection, and various analytical approaches that could be used to enhance the detection sensitivity of Raman spectroscopy-based detection. This is followed by a detailed discussion about the fiber-based optofluidic Raman detection systems.
Original languageEnglish
Title of host publicationspectroscopyOptical Nano- and Microsystems for Bioanalytics, Springer Series on Chemical Sensors and Biosensors
ISBN (Electronic)9783642254987
Publication statusPublished - 2012

Publication series

NameSensors and Biosensors


  • Microfluidics
  • Raman spectroscopy


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