Microfluidic optical sorting: particle selection in an optical lattice

M P MacDonalda, S Neale, L Paterson, A Riches, G C Spalding, K Dholakia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The path that a mesoscopic polarisable particle takes as it flows through a lattice of intensity maxima and minima (optical lattice) depends crucially upon the degree to which it interacts with the lattice. Two particles of dissimilar size, refractive index or even shape will interact in a different manner with such a lattice. Combining this selective interaction with a guiding mechanism has allowed us to achieve lateral separation of particles by all these properties simply by flowing them through an angled optical lattice. We present such particle separation in a variety of three-dimensional optical lattices discussing the importance of parameters such as flow speed, lattice intensity, lattice constant, lattice angle, maxima interconnectivity and flow chamber design. We also present cell sorting with the separation of erythrocytes from lymphocytes and present our flow chamber fabrication methods.

Original languageEnglish
Title of host publicationOPTICAL TRAPPING AND OPTICAL MICROMANIPULATION
EditorsK Dholakia, GC Spalding
Place of PublicationBELLINGHAM
PublisherSPIE
Pages1-14
Number of pages14
ISBN (Print)0-8194-5452-4
Publication statusPublished - 2004
EventConference on Optical Trapping and Optical Micromanipulation - Denver
Duration: 2 Aug 20046 Aug 2004

Conference

ConferenceConference on Optical Trapping and Optical Micromanipulation
CityDenver
Period2/08/046/08/04

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