Micro-evolution of Burkholderia pseudomallei during an acute infection

Direk Limmathurotsakul, Matthew T G Holden, Paul Coupland, Erin P Price, Narisara Chantratita, Vanaporn Wuthiekanun, Premjit Amornchai, Julian Parkhill, Sharon J Peacock

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19 Citations (Scopus)


We used whole-genome sequencing to evaluate sixty-nine independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for rapid in vivo diversification of B. pseudomallei after inoculation, and systemic spread of a heterogeneous population.
Original languageEnglish
JournalJournal of Clinical Microbiology
Early online date25 Jun 2014
Publication statusPublished - 2014


  • Melioidosis
  • Burkholderia pseudomallei
  • Whole genome sequencing
  • Within-host evolution

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