Metal-driven folding and assembly of a minimal β-sheet into a 3D-porous honeycomb framework

Nikhil Bajpayee; Salil Pophali; Thangavel Vijayakanth; Shyamapada Nandi; Aamod V Desai; Vinod Kumar; Rahul Jain; Santu Bera; Linda J W Shimon; Rajkumar Misra

doi:10.1039/d3cc05185d

Metal-driven folding and assembly of a minimal β-sheet into a 3D-porous honeycomb framework

Nikhil Bajpayee, Salil Pophali, Thangavel Vijayakanth, Shyamapada Nandi, Aamod V Desai, Vinod Kumar, Rahul Jain, Santu Bera, Linda J W Shimon^*, Rajkumar Misra^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

In contrast to short helical peptides, constrained peptides, and foldamers, the design and fabrication of crystalline 3D frameworks from the β-sheet peptides are rare because of their high self-aggregation propensity to form 1D architectures. Herein, we demonstrate the formation of a 3D porous honeycomb framework through the silver coordination of a minimal β-sheet forming a peptide having terminal metal coordinated 4- and 3-pyridyl ligands.

Original language	English
Number of pages	4
Journal	Chemical Communications
Volume	Advance Article
Early online date	25 Jan 2024
DOIs	https://doi.org/10.1039/d3cc05185d
Publication status	E-pub ahead of print - 25 Jan 2024

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10.1039/d3cc05185d

Bajpayee_2024_CC_Metal-driven_AAM
Copyright © 2024 the Authors. This work has been made available online in accordance with the University of St Andrews Open Access policy. This accepted manuscript is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The final published version of this work is available at https://doi.org/10.1039/D3CC05185D
Accepted author manuscript, 988 KBLicence: CC BY

CCDC 2290690: Experimental Crystal Structure Determination
Bajpayee, N. (Creator), Pophali, S. (Creator), Vijayakanth, T. (Creator), Nandi, S. (Creator), Desai, A. (Creator), Kumar, V. (Creator), Jain, R. (Creator), Bera, S. (Creator), Shimon, L. (Creator) & Misra, R. (Creator), Cambridge Crystallographic Data Centre, 2025
DOI: 10.5517/ccdc.csd.cc2gwn78
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@article{409a92b0f2fe4fd2a781391be521d45c,

title = "Metal-driven folding and assembly of a minimal β-sheet into a 3D-porous honeycomb framework",

abstract = "In contrast to short helical peptides, constrained peptides, and foldamers, the design and fabrication of crystalline 3D frameworks from the β-sheet peptides are rare because of their high self-aggregation propensity to form 1D architectures. Herein, we demonstrate the formation of a 3D porous honeycomb framework through the silver coordination of a minimal β-sheet forming a peptide having terminal metal coordinated 4- and 3-pyridyl ligands.",

author = "Nikhil Bajpayee and Salil Pophali and Thangavel Vijayakanth and Shyamapada Nandi and Desai, {Aamod V} and Vinod Kumar and Rahul Jain and Santu Bera and Shimon, {Linda J W} and Rajkumar Misra",

note = "This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499), and National Institute of Pharmaceutical Education and Research, S. A. S. Nagar. S. B. thanks SERB, Govt. of India for the Ramanujan Fellowship (ref. no. RJF/2022/000042) and Ashoka University.",

year = "2024",

month = jan,

day = "25",

doi = "10.1039/d3cc05185d",

language = "English",

volume = "Advance Article",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Metal-driven folding and assembly of a minimal β-sheet into a 3D-porous honeycomb framework

AU - Bajpayee, Nikhil

AU - Pophali, Salil

AU - Vijayakanth, Thangavel

AU - Nandi, Shyamapada

AU - Desai, Aamod V

AU - Kumar, Vinod

AU - Jain, Rahul

AU - Bera, Santu

AU - Shimon, Linda J W

AU - Misra, Rajkumar

N1 - This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499), and National Institute of Pharmaceutical Education and Research, S. A. S. Nagar. S. B. thanks SERB, Govt. of India for the Ramanujan Fellowship (ref. no. RJF/2022/000042) and Ashoka University.

PY - 2024/1/25

Y1 - 2024/1/25

N2 - In contrast to short helical peptides, constrained peptides, and foldamers, the design and fabrication of crystalline 3D frameworks from the β-sheet peptides are rare because of their high self-aggregation propensity to form 1D architectures. Herein, we demonstrate the formation of a 3D porous honeycomb framework through the silver coordination of a minimal β-sheet forming a peptide having terminal metal coordinated 4- and 3-pyridyl ligands.

AB - In contrast to short helical peptides, constrained peptides, and foldamers, the design and fabrication of crystalline 3D frameworks from the β-sheet peptides are rare because of their high self-aggregation propensity to form 1D architectures. Herein, we demonstrate the formation of a 3D porous honeycomb framework through the silver coordination of a minimal β-sheet forming a peptide having terminal metal coordinated 4- and 3-pyridyl ligands.

U2 - 10.1039/d3cc05185d

DO - 10.1039/d3cc05185d

M3 - Article

C2 - 38299634

SN - 1359-7345

VL - Advance Article

JO - Chemical Communications

JF - Chemical Communications

ER -

Metal-driven folding and assembly of a minimal β-sheet into a 3D-porous honeycomb framework

Abstract

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Datasets

CCDC 2290690: Experimental Crystal Structure Determination

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