Metabolic reprogramming during the Trypanosoma brucei life cycle

Terry K. Smith; Frédéric Bringaud; Derek P. Nolan; Luisa M. Figueiredo

doi:10.12688/f1000research.10342.2

Metabolic reprogramming during the Trypanosoma brucei life cycle

Terry K. Smith, Frédéric Bringaud, Derek P. Nolan, Luisa M. Figueiredo

Research output: Contribution to journal › Review article › peer-review

Abstract

Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.

Original language	English
Article number	683
Journal	F1000Research
Volume	6
Early online date	16 May 2017
DOIs	https://doi.org/10.12688/f1000research.10342.2
Publication status	Published - 18 May 2017

Keywords

Trypanosoma brucei
Metabolism
Adaptations

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.12688/f1000research.10342.2Licence: CC BY

Smith_2017_F1000R_Reprogramming_CC
© 2017 Smith TK et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.56 MBLicence: CC BY

Cite this

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title = "Metabolic reprogramming during the Trypanosoma brucei life cycle",

abstract = "Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.",

keywords = "Trypanosoma brucei, Metabolism, Adaptations",

author = "Smith, {Terry K.} and Fr{\'e}d{\'e}ric Bringaud and Nolan, {Derek P.} and Figueiredo, {Luisa M.}",

note = "TKS is supported by the Wellcome Trust, the Biotechnology and Biological Sciences Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council (MR/M020118/1) and the European Community Seventh Framework Programme under grant agreement 602773 (Project KINDRED). FB is supported by the Centre National de la Recherche Scientifique (CNRS), the Universit{\'e} de Bordeaux, the Agence Nationale de la Recherche (ANR) through the GLYCONOV grant (ANR-15-CE15-0025-01) of the {\textquoteleft}G{\'e}n{\'e}rique{\textquoteright} 2015 call and the Laboratoire d{\textquoteright}Excellence (LabEx) ParaFrap (grant ANR-11-LABX-0024). DPN is supported by the Wellcome Trust and Science Foundation Ireland. LMF is supported by the Howard Hughes Medical Institute (55007419) and the Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT) (PTDC/BIM-MET/4471/2014). ",

year = "2017",

month = may,

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doi = "10.12688/f1000research.10342.2",

language = "English",

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AU - Smith, Terry K.

AU - Bringaud, Frédéric

AU - Nolan, Derek P.

AU - Figueiredo, Luisa M.

N1 - TKS is supported by the Wellcome Trust, the Biotechnology and Biological Sciences Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council (MR/M020118/1) and the European Community Seventh Framework Programme under grant agreement 602773 (Project KINDRED). FB is supported by the Centre National de la Recherche Scientifique (CNRS), the Université de Bordeaux, the Agence Nationale de la Recherche (ANR) through the GLYCONOV grant (ANR-15-CE15-0025-01) of the ‘Générique’ 2015 call and the Laboratoire d’Excellence (LabEx) ParaFrap (grant ANR-11-LABX-0024). DPN is supported by the Wellcome Trust and Science Foundation Ireland. LMF is supported by the Howard Hughes Medical Institute (55007419) and the Fundação para a Ciência e a Tecnologia (FCT) (PTDC/BIM-MET/4471/2014).

PY - 2017/5/18

Y1 - 2017/5/18

N2 - Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.

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KW - Trypanosoma brucei

KW - Metabolism

KW - Adaptations

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ER -

Metabolic reprogramming during the Trypanosoma brucei life cycle

Abstract

Keywords

UN SDGs

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Other files and links

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lipid catabolism: Investigating the typanosomatid lysosome and its role in lipid catabolism.

EU KINDRED: EU KINDRED-Management

Investigating Trypanosoma brucei's: Investigating Trypanosoma Brucei's Unusual Inositol Metabolism

Cite this

Metabolic reprogramming during the Trypanosoma brucei life cycle

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

lipid catabolism: Investigating the typanosomatid lysosome and its role in lipid catabolism.

EU KINDRED: EU KINDRED-Management

Investigating Trypanosoma brucei's: Investigating Trypanosoma Brucei's Unusual Inositol Metabolism

Cite this