Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Lijun Wang; Yue Min; Doudou Xu; Fengjiao Yu; Wuzong Zhou; Alfred Cuschieri

doi:10.1039/c4cc03082f

Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Lijun Wang^*, Yue Min, Doudou Xu, Fengjiao Yu, Wuzong Zhou, Alfred Cuschieri

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

Original language	English
Pages (from-to)	11147-11150
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	76
DOIs	https://doi.org/10.1039/c4cc03082f
Publication status	Published - 2014

Keywords

IRON-OXIDE NANOPARTICLES
CYTOTOXICITY
OXIDATION
CATALYSTS
MECHANISM

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10.1039/c4cc03082f

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title = "Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles",

abstract = "We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.",

keywords = "IRON-OXIDE NANOPARTICLES, CYTOTOXICITY, OXIDATION, CATALYSTS, MECHANISM",

author = "Lijun Wang and Yue Min and Doudou Xu and Fengjiao Yu and Wuzong Zhou and Alfred Cuschieri",

year = "2014",

doi = "10.1039/c4cc03082f",

language = "English",

volume = "50",

pages = "11147--11150",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

AU - Wang, Lijun

AU - Min, Yue

AU - Xu, Doudou

AU - Yu, Fengjiao

AU - Zhou, Wuzong

AU - Cuschieri, Alfred

PY - 2014

Y1 - 2014

N2 - We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

AB - We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

KW - IRON-OXIDE NANOPARTICLES

KW - CYTOTOXICITY

KW - OXIDATION

KW - CATALYSTS

KW - MECHANISM

U2 - 10.1039/c4cc03082f

DO - 10.1039/c4cc03082f

M3 - Article

SN - 1359-7345

VL - 50

SP - 11147

EP - 11150

JO - Chemical Communications

JF - Chemical Communications

IS - 76

ER -

Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Abstract

Keywords

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