Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Lijun Wang*, Yue Min, Doudou Xu, Fengjiao Yu, Wuzong Zhou, Alfred Cuschieri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

Original languageEnglish
Pages (from-to)11147-11150
Number of pages4
JournalChemical Communications
Volume50
Issue number76
DOIs
Publication statusPublished - 2014

Keywords

  • IRON-OXIDE NANOPARTICLES
  • CYTOTOXICITY
  • OXIDATION
  • CATALYSTS
  • MECHANISM

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