Projects per year
Abstract
This proof-of-concept study cements the viability and generality of mechanophotocatalysis, merging mechanochemistry and photocatalysis to enable solvent-minimized photocatalytic reactions. We demonstrate the transmutation of four archetypal solution-state photocatalysis reactions to a solvent-minimized environment driven by the combined actions of milling, light, and photocatalysts. The chlorosulfonylation of alkenes and the pinacol coupling of aldehydes and ketones were conducted under solvent-free conditions with competitive or superior efficiencies to their solution-state analogues. Furthermore, decarboxylative alkylations are shown to function efficiently under solvent-minimized conditions, while the photoinduced energy transfer promoted [2+2] cycloaddition of chalcone experiences a significant initial rate enhancement over its solution-state variant. This work serves as a platform for future discoveries in an underexplored field: validating that solvent-minimized photocatalysis is not only generalizable and competitive with solution-state photocatalysis, but can also offer valuable advantages.
Original language | English |
---|---|
Article number | e202316169 |
Number of pages | 10 |
Journal | Angewandte Chemie International Edition |
Volume | Early View |
Early online date | 19 Feb 2024 |
DOIs | |
Publication status | E-pub ahead of print - 19 Feb 2024 |
Keywords
- Mechanochemistry
- Photocatalysis
- Synthetic methods
- Mechanophotocatalysis
- Radicals
Fingerprint
Dive into the research topics of 'Mechanophotocatalysis: a generalizable approach to solvent-minimized photocatalytic reactions for organic synthesis'. Together they form a unique fingerprint.-
MechanophotocatalysiS: Mechanophotocatalysis: a new frontier for solvent-minimized photocatalysis react
Zysman-Colman, E. (PI)
1/09/23 → 31/08/27
Project: Standard
-
Allan Watson Programme Grant: Boron: Beyond the Reagent
Watson, A. J. B. (PI), Morris, R. E. (CoI), Smith, A. D. (CoI) & Zysman-Colman, E. (CoI)
1/05/23 → 30/04/28
Project: Standard
-
MR TADF: Multi-resonance TADF materials for highly efficient and stable OLEDs
Zysman-Colman, E. (PI)
1/07/22 → 30/06/25
Project: Standard
Datasets
-
Mechanophotocatalysis: A Generalizable Approach to Solventminimized Photocatalytic Reactions for Organic Synthesis (dataset)
Zysman-Colman, E. (Creator) & Millward, F. D. (Creator), University of St Andrews, 24 Jan 2024
DOI: 10.17630/edf5b7a2-1ca9-4c29-a8a2-8828fb666418
Dataset
File