Mechanisms of oligodendrocyte interaction with normal human serum--defining the role of complement

J Zajicek, M G Wing, P J Lachmann, D A Compston

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The interaction of human serum with oligodendroglia was investigated in vitro using purified cultured neonatal rat oligodendrocytes. Previous evidence for antibody independent classical pathway complement activation was confirmed; the results also showed a deficit in the protection of rat oligodendrocytes from complement attack suggesting a deficiency in the expression of terminal regulatory proteins of the complement cascade. Thus, rat oligodendrocytes are selectively sensitive to normal serum due both to complement activation and impaired protection from terminal complement attack.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalJournal of the Neurological Sciences
Volume108
Issue number1
Publication statusPublished - Mar 1992

Keywords

  • Animals
  • Animals, Newborn
  • Astrocytes
  • Blood Physiological Phenomena
  • Blood-Brain Barrier
  • Cells, Cultured
  • Complement C1
  • Complement C3
  • Complement Membrane Attack Complex
  • Complement Pathway, Classical
  • Demyelinating Diseases
  • Oligodendroglia
  • Rats
  • Rats, Inbred Strains

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