Mechanisms of cyanobactin biosynthesis

Clarissa Melo Czekster, Ying Ge, James H. Naismith

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)

Abstract

Cyanobactins are a diverse collection of natural products that originate from short peptides made on a ribosome. The amino acids are modified in a series of transformations catalyzed by multiple enzymes. The patellamide pathway is the most well studied and characterized example. Here we review the structures and mechanisms of the enzymes that cleave peptide bonds, macrocyclise peptides, heterocyclise cysteine (as well as threonine and serine) residues, oxidize five-membered heterocycles and attach prenyl groups. Some enzymes operate by novel mechanisms which is of interest and in addition the enzymes uncouple recognition from catalysis. The normally tight relationship between these factors hinders biotechnology. The cyanobactin pathway may be particularly suitable for exploitation, with progress observed with in vivo and in vitro approaches.
Original languageEnglish
Pages (from-to)80-88
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume35
Early online date14 Sept 2016
DOIs
Publication statusPublished - Dec 2016

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