Mechanism of Racemization of Chiral Alcohols Mediated by 16-Electron Ruthenium Complexes

Johann Bosson; Albert Poater; Luigi Cavallo; Steven Patrick Nolan

doi:10.1021/ja104961s

Mechanism of Racemization of Chiral Alcohols Mediated by 16-Electron Ruthenium Complexes

Johann Bosson, Albert Poater, Luigi Cavallo, Steven Patrick Nolan

Research output: Contribution to journal › Article › peer-review

Abstract

Experimental and computational analyses provide support for the existence of a metal-hydride-based mechanism for the ruthenium-mediated racemization of chiral alcohols.

Original language	English
Pages (from-to)	13146-13149
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	132
Issue number	38
DOIs	https://doi.org/10.1021/ja104961s
Publication status	Published - 29 Sept 2010

Keywords

DYNAMIC KINETIC RESOLUTION
ASYMMETRIC TRANSFER HYDROGENATION
SHVOS DIRUTHENIUM COMPLEX
SECONDARY ALCOHOLS
AMBIENT-TEMPERATURE
NUCLEOPHILIC CARBENE
METAL CATALYSIS
HYDRIDE
LIGANDS
ELIMINATION

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10.1021/ja104961s

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title = "Mechanism of Racemization of Chiral Alcohols Mediated by 16-Electron Ruthenium Complexes",

abstract = "Experimental and computational analyses provide support for the existence of a metal-hydride-based mechanism for the ruthenium-mediated racemization of chiral alcohols.",

keywords = "DYNAMIC KINETIC RESOLUTION, ASYMMETRIC TRANSFER HYDROGENATION, SHVOS DIRUTHENIUM COMPLEX, SECONDARY ALCOHOLS, AMBIENT-TEMPERATURE, NUCLEOPHILIC CARBENE, METAL CATALYSIS, HYDRIDE, LIGANDS, ELIMINATION",

author = "Johann Bosson and Albert Poater and Luigi Cavallo and Nolan, \{Steven Patrick\}",

year = "2010",

month = sep,

day = "29",

doi = "10.1021/ja104961s",

language = "English",

volume = "132",

pages = "13146--13149",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society (ACS)",

number = "38",

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TY - JOUR

T1 - Mechanism of Racemization of Chiral Alcohols Mediated by 16-Electron Ruthenium Complexes

AU - Bosson, Johann

AU - Poater, Albert

AU - Cavallo, Luigi

AU - Nolan, Steven Patrick

PY - 2010/9/29

Y1 - 2010/9/29

N2 - Experimental and computational analyses provide support for the existence of a metal-hydride-based mechanism for the ruthenium-mediated racemization of chiral alcohols.

AB - Experimental and computational analyses provide support for the existence of a metal-hydride-based mechanism for the ruthenium-mediated racemization of chiral alcohols.

KW - DYNAMIC KINETIC RESOLUTION

KW - ASYMMETRIC TRANSFER HYDROGENATION

KW - SHVOS DIRUTHENIUM COMPLEX

KW - SECONDARY ALCOHOLS

KW - AMBIENT-TEMPERATURE

KW - NUCLEOPHILIC CARBENE

KW - METAL CATALYSIS

KW - HYDRIDE

KW - LIGANDS

KW - ELIMINATION

UR - https://www.scopus.com/pages/publications/77957106009

U2 - 10.1021/ja104961s

DO - 10.1021/ja104961s

M3 - Article

SN - 0002-7863

VL - 132

SP - 13146

EP - 13149

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 38

ER -

Mechanism of Racemization of Chiral Alcohols Mediated by 16-Electron Ruthenium Complexes

Abstract

Keywords

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