Mating system manipulation and the evolution of sex-biased gene expression in Drosophila

Paris Veltsos; Yongxiang Fang; Andrew R. Cossins; Rhonda R. Snook; Michael Gordon Ritchie

doi:10.1038/s41467-017-02232-6

Mating system manipulation and the evolution of sex-biased gene expression in Drosophila

Paris Veltsos, Yongxiang Fang, Andrew R. Cossins, Rhonda R. Snook, Michael Gordon Ritchie

Research output: Contribution to journal › Article › peer-review

Abstract

Sex differences in dioecious animals are pervasive and result from gene expression differences. Elevated sexual selection has been predicted to increase the number and expression of male-biased genes, and experimentally imposing monogamy on Drosophila melanogaster has led to a relative feminisation of the transcriptome. Here, we test this hypothesis further by subjecting another polyandrous species, D. pseudoobscura, to 150 generations of experimental monogamy or elevated polyandry. We find that sex-biased genes do change in expression but, contrary to predictions, there is usually masculinisation of the transcriptome under monogamy, although this depends on tissue and sex. We also identify and describe gene expression changes following courtship experience. Courtship often influences gene expression, including patterns in sex-biased gene expression. Our results confirm that mating system manipulation disproportionately influences sex-biased gene expression but show that the direction of change is dynamic and unpredictable.

Original language	English
Article number	2072
Number of pages	11
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/s41467-017-02232-6
Publication status	Published - 12 Dec 2017

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Final published version, 1.02 MBLicence: CC BY

Evolution of gene expression: Evolution of gene expression in response to sexual selection
Ritchie, M. G. (PI)
NERC
1/07/11 → 30/06/14
Project: Standard

Michael Gordon Ritchie
- mgrst-andrews.acuk
Person: Academic

A pipeline to detect the direction of feminisation after experimental evolution using edgeR and stdLogFC
Veltsos, P. (Creator), Zenodo, 9 Nov 2017
DOI: 10.5281/zenodo.1044633
Dataset
Mating system manipulation and the evolution of sex-biased gene expression in Drosophila (dataset)
Veltsos, P. (Creator), Fang, Y. (Creator), Cossins, A. R. (Creator), Snook, R. R. (Creator) & Ritchie, M. G. (Creator), EMBL-EBI, 24 Nov 2017
https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-4486
Dataset

Cite this

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title = "Mating system manipulation and the evolution of sex-biased gene expression in Drosophila",

abstract = "Sex differences in dioecious animals are pervasive and result from gene expression differences. Elevated sexual selection has been predicted to increase the number and expression of male-biased genes, and experimentally imposing monogamy on Drosophila melanogaster has led to a relative feminisation of the transcriptome. Here, we test this hypothesis further by subjecting another polyandrous species, D. pseudoobscura, to 150 generations of experimental monogamy or elevated polyandry. We find that sex-biased genes do change in expression but, contrary to predictions, there is usually masculinisation of the transcriptome under monogamy, although this depends on tissue and sex. We also identify and describe gene expression changes following courtship experience. Courtship often influences gene expression, including patterns in sex-biased gene expression. Our results confirm that mating system manipulation disproportionately influences sex-biased gene expression but show that the direction of change is dynamic and unpredictable.",

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AU - Ritchie, Michael Gordon

N1 - Funding: Natural Environment Research Council grant (NE/I014632/1) to MGR, RRS & ARC, and an associated NBAF award (NBAF654).

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AB - Sex differences in dioecious animals are pervasive and result from gene expression differences. Elevated sexual selection has been predicted to increase the number and expression of male-biased genes, and experimentally imposing monogamy on Drosophila melanogaster has led to a relative feminisation of the transcriptome. Here, we test this hypothesis further by subjecting another polyandrous species, D. pseudoobscura, to 150 generations of experimental monogamy or elevated polyandry. We find that sex-biased genes do change in expression but, contrary to predictions, there is usually masculinisation of the transcriptome under monogamy, although this depends on tissue and sex. We also identify and describe gene expression changes following courtship experience. Courtship often influences gene expression, including patterns in sex-biased gene expression. Our results confirm that mating system manipulation disproportionately influences sex-biased gene expression but show that the direction of change is dynamic and unpredictable.

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Mating system manipulation and the evolution of sex-biased gene expression in Drosophila

Abstract

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Evolution of gene expression: Evolution of gene expression in response to sexual selection

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Michael Gordon Ritchie

Datasets

A pipeline to detect the direction of feminisation after experimental evolution using edgeR and stdLogFC

Mating system manipulation and the evolution of sex-biased gene expression in Drosophila (dataset)

Cite this