Mathematical modelling of cancer invasion: phenotypic transitioning provides insight into multifocal foci formation

Zuzanna Szymańska*, Mirosław Lachowicz, Nikolaos Sfakianakis, Mark A. J. Chaplain

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Downloads (Pure)

Abstract

The transition from the epithelial to mesenchymal phenotype and its reverse (from mesenchymal to epithelial) are crucial processes necessary for the progression and spread of cancer. In this paper, we investigate how phenotypic switching at the cancer cell level impacts on behaviour at the tissue level, specifically on the emergence of isolated foci of the invading solid tumour mass leading to a multifocal tumour. To this end, we propose a new mathematical model of cancer invasion that includes the influence of cancer cell phenotype on the rate of invasion and metastasis. The implications of model are explored through numerical simulations revealing that the plasticity of tumour cell phenotypes appears to be crucial for disease progression and local invasive spread. The computational simulations show the progression of the invasive spread of a primary cancer reminiscent of in vivo multifocal breast carcinomas, where multiple, synchronous, ipsilateral neoplastic foci are frequently observed and are associated with a poorer patient prognosis.
Original languageEnglish
Article number102175
Number of pages15
JournalJournal of Computational and Applied Mathematics
Volume75
Early online date30 Nov 2023
DOIs
Publication statusPublished - 1 Jan 2024

Keywords

  • Cancer invasion
  • Phenotypic switching
  • Epithelial-mesenchymal transition
  • Invasive foci
  • Multifocal cancer

Fingerprint

Dive into the research topics of 'Mathematical modelling of cancer invasion: phenotypic transitioning provides insight into multifocal foci formation'. Together they form a unique fingerprint.

Cite this