Mathematical modeling of tumor-induced angiogenesis

M. A. J. Chaplain, S. R. McDougall, A. R. A. Anderson

Research output: Contribution to journalArticlepeer-review

224 Citations (Scopus)

Abstract

Angiogenesis, the growth of a network of blood vessels, is a crucial component of solid tumor growth, linking the relatively harmless avascular and the potentially fatal vascular growth phases of the tumor. As a process, angiogenesis is a well-orchestrated sequence of events involving endothelial cell migration and proliferation; degradation of tissue; new capillary vessel formation; loop formation (anastomosis) and, crucially, blood flow through the network. Once there is flow associated with the nascent network, subsequent growth evolves both temporally and spatially in response to the combined effects of angiogenic factors, migratory cues via the extracellular matrix, and perfusion-related hemodynamic forces in a manner that may be described as both adaptive and dynamic. In this article, we first present a review of previous theoretical and computational models of angiogenesis and then indicate how recent developments in flow models are providing insight into antiangiogenic and chemotherapeutic drug treatment of solid tumors.
Original languageEnglish
Pages (from-to)233-257
Number of pages25
JournalAnnual Review of Biomedical Engineering
Volume8
DOIs
Publication statusPublished - 2006

Keywords

  • Angiogenesis
  • Mathematical modelling
  • Solid tumours

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