Mapuera virus inhibits IFN signalling in a wide variety of mammalian cells without degrading STATs

K Hagmaier, N Stock, B Precious, K Childs, L-F Wang, S Goodbourn, Richard Edward Randall

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Majouera virus (MPRV) is a paramyxovirus that was originally isolated from bats, but its host range remains unknown. It was classified as a member of the genus Rubulavirus on the basis of structural and genetic features. Like other rubulaviruses it encodes a V protein (MPRV/V) that functions as an interferon (IFN) antagonist. Here we show that MPRV/V differs from the IFN antagonists of other rubulaviruses in that it does not induce the proteasomal degradation of STAT proteins, key factors in the IFN signalling cascade. Rather, MPRV/V prevents the nuclear translocation of STATs in response to IFN stimulation and inhibits the formation of the transcription factor complex ISGF3. We also show that MPRV/V blocks IFN signalling in cells from diverse mammalian species and discuss the IFN response as a barrier to cross-species infections.

Original languageEnglish
Pages (from-to)956-66
Number of pages11
JournalJournal of General Virology
Volume88
DOIs
Publication statusPublished - Mar 2007

Keywords

  • UBIQUITIN LIGASE COMPLEXES
  • PARAMYXOVIRUS-V PROTEIN
  • AMINO-ACID SUBSTITUTION
  • ALPHA/BETA-INTERFERON
  • BINDING-PROTEIN
  • HOST-RANGE
  • NUCLEAR ACCUMULATION
  • ANTIVIRAL RESPONSES
  • GAMMA-INTERFERON
  • PREVENTING STAT1

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