Manipulating Replication Processes within a Dynamic Covalent Framework

Vicente del Amo; Alexandra M. Z. Slawin; Douglas Philp

doi:10.1021/ol8018665

Manipulating Replication Processes within a Dynamic Covalent Framework

Vicente del Amo, Alexandra M. Z. Slawin, Douglas Philp

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

The reaction of an amine bearing an amidopyridine recognition site and an aldehyde bearing a carboxylic acid recognition site affords an imine that is capable of directing its own formation through a dynamic covalent replication cycle. Additionally, the amine, formed by reduction of the replicating imine, is a more efficient catalyst for the formation of the replicating imine than the imine is a catalyst for its own formation.

Original language	English
Pages (from-to)	4589-4592
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	20
DOIs	https://doi.org/10.1021/ol8018665
Publication status	Published - 16 Oct 2008

Keywords

VIRTUAL COMBINATORIAL LIBRARIES
SYSTEMS CHEMISTRY
SELF-REPLICATION
THERMODYNAMIC CONTROL
EFFECTIVE MOLARITIES
AQUEOUS-SOLUTION
SUBSTITUTION
SELECTIVITY
GENERATION
CATALYSIS

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10.1021/ol8018665

Cite this

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title = "Manipulating Replication Processes within a Dynamic Covalent Framework",

abstract = "The reaction of an amine bearing an amidopyridine recognition site and an aldehyde bearing a carboxylic acid recognition site affords an imine that is capable of directing its own formation through a dynamic covalent replication cycle. Additionally, the amine, formed by reduction of the replicating imine, is a more efficient catalyst for the formation of the replicating imine than the imine is a catalyst for its own formation.",

keywords = "VIRTUAL COMBINATORIAL LIBRARIES, SYSTEMS CHEMISTRY, SELF-REPLICATION, THERMODYNAMIC CONTROL, EFFECTIVE MOLARITIES, AQUEOUS-SOLUTION, SUBSTITUTION, SELECTIVITY, GENERATION, CATALYSIS",

author = "{del Amo}, Vicente and Slawin, {Alexandra M. Z.} and Douglas Philp",

year = "2008",

month = oct,

day = "16",

doi = "10.1021/ol8018665",

language = "English",

volume = "10",

pages = "4589--4592",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society (ACS)",

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T1 - Manipulating Replication Processes within a Dynamic Covalent Framework

AU - del Amo, Vicente

AU - Slawin, Alexandra M. Z.

AU - Philp, Douglas

PY - 2008/10/16

Y1 - 2008/10/16

N2 - The reaction of an amine bearing an amidopyridine recognition site and an aldehyde bearing a carboxylic acid recognition site affords an imine that is capable of directing its own formation through a dynamic covalent replication cycle. Additionally, the amine, formed by reduction of the replicating imine, is a more efficient catalyst for the formation of the replicating imine than the imine is a catalyst for its own formation.

AB - The reaction of an amine bearing an amidopyridine recognition site and an aldehyde bearing a carboxylic acid recognition site affords an imine that is capable of directing its own formation through a dynamic covalent replication cycle. Additionally, the amine, formed by reduction of the replicating imine, is a more efficient catalyst for the formation of the replicating imine than the imine is a catalyst for its own formation.

KW - VIRTUAL COMBINATORIAL LIBRARIES

KW - SYSTEMS CHEMISTRY

KW - SELF-REPLICATION

KW - THERMODYNAMIC CONTROL

KW - EFFECTIVE MOLARITIES

KW - AQUEOUS-SOLUTION

KW - SUBSTITUTION

KW - SELECTIVITY

KW - GENERATION

KW - CATALYSIS

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U2 - 10.1021/ol8018665

DO - 10.1021/ol8018665

M3 - Article

SN - 1523-7060

VL - 10

SP - 4589

EP - 4592

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Manipulating Replication Processes within a Dynamic Covalent Framework

Abstract

Keywords

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EPSRC: PROBING CROSSCATALYSIS: Probing Crosscatalysis, Autocatalysis and Amplific

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Manipulating Replication Processes within a Dynamic Covalent Framework

Abstract

Keywords

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EPSRC: PROBING CROSSCATALYSIS: Probing Crosscatalysis, Autocatalysis and Amplific

Cite this