Manganese catalyzed hydrogenation of enantiomerically pure esters

Magnus B. Widegren, Matthew L. Clarke

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)
14 Downloads (Pure)


A manganese-catalyzed hydrogenation of esters has been accomplished with TON up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.
Original languageEnglish
Pages (from-to)2654-2658
Number of pages5
JournalOrganic Letters
Issue number9
Early online date19 Apr 2018
Publication statusPublished - 4 May 2018


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