Manganese catalyzed hydrogenation of enantiomerically pure esters

Magnus B. Widegren; Matthew L. Clarke

doi:10.1021/acs.orglett.8b00864

Manganese catalyzed hydrogenation of enantiomerically pure esters

Research output: Contribution to journal › Article › peer-review

Abstract

A manganese-catalyzed hydrogenation of esters has been accomplished with TON up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.

Original language	English
Pages (from-to)	2654-2658
Number of pages	5
Journal	Organic Letters
Volume	20
Issue number	9
Early online date	19 Apr 2018
DOIs	https://doi.org/10.1021/acs.orglett.8b00864
Publication status	Published - 4 May 2018

Access to Document

10.1021/acs.orglett.8b00864

MnCat enantio pure estersrevisedPDF
Copyright © 2018 American Chemical Society. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1021/acs.orglett.8b00864
Accepted author manuscript, 498 KB

Data underpinning - Manganese catalyzed hydrogenation of enantiomerically pure esters
Widegren, M. B. (Creator) & Clarke, M. L. (Supervisor), University of St Andrews, 20 Apr 2018
DOI: 10.17630/29308cf7-b6b6-4b1b-809b-a12fe91b250f
Dataset

File

Cite this

@article{2477b1bf1f164f5f938c4adc5e57c9e9,

title = "Manganese catalyzed hydrogenation of enantiomerically pure esters",

abstract = "A manganese-catalyzed hydrogenation of esters has been accomplished with TON up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.",

author = "Widegren, {Magnus B.} and Clarke, {Matthew L.}",

note = "The authors thank the EPSRC for DTG funding for MBW. The technical support staff at St Andrews are also gratefully acknowledged. The research data supporting this publication can be accessed at: dx.doi.org/10.17630/29308cf7-b6b6- 4b1b-809b-a12fe91b250f",

year = "2018",

month = may,

day = "4",

doi = "10.1021/acs.orglett.8b00864",

language = "English",

volume = "20",

pages = "2654--2658",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society (ACS)",

number = "9",

}

TY - JOUR

T1 - Manganese catalyzed hydrogenation of enantiomerically pure esters

AU - Widegren, Magnus B.

AU - Clarke, Matthew L.

N1 - The authors thank the EPSRC for DTG funding for MBW. The technical support staff at St Andrews are also gratefully acknowledged. The research data supporting this publication can be accessed at: dx.doi.org/10.17630/29308cf7-b6b6- 4b1b-809b-a12fe91b250f

PY - 2018/5/4

Y1 - 2018/5/4

N2 - A manganese-catalyzed hydrogenation of esters has been accomplished with TON up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.

AB - A manganese-catalyzed hydrogenation of esters has been accomplished with TON up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.

U2 - 10.1021/acs.orglett.8b00864

DO - 10.1021/acs.orglett.8b00864

M3 - Article

SN - 1523-7060

VL - 20

SP - 2654

EP - 2658

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Manganese catalyzed hydrogenation of enantiomerically pure esters

Abstract

Access to Document

Fingerprint

Datasets

Data underpinning - Manganese catalyzed hydrogenation of enantiomerically pure esters

Cite this