Manganese catalysed enantioselective hydrogenation of in-situ-synthesised imines: efficient asymmetric synthesis of amino-indane derivatives

Conor Oates; Alister S. Goodfellow; Michael Buehl; Matthew L. Clarke

doi:10.1039/D3GC00399J

Manganese catalysed enantioselective hydrogenation of in-situ-synthesised imines: efficient asymmetric synthesis of amino-indane derivatives

Conor Oates, Alister S. Goodfellow, Michael Buehl, Matthew L. Clarke^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A manganese catalyst of a facially coordinating P,N,N ligand catalyses the hydrogenation of imines derived from indanone derivatives with high enantioselectivity. There is no requirement for an activating group and imines can be generated in situ. The selectivity can be rationalised by DFT calculations.

Original language	English
Pages (from-to)	3864-3868
Number of pages	5
Journal	Green Chemistry
Volume	25
Issue number	10
Early online date	3 May 2023
DOIs	https://doi.org/10.1039/D3GC00399J
Publication status	Published - 21 May 2023

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10.1039/D3GC00399JLicence: CC BY

Oates_2023_GC_Manganese-catalysed_CC
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CRITICAT - EASiCAT Studentship: CRITICAT - EASiCAT Studentship
Smith, A. D. (PI)
EPSRC
1/04/21 → 31/10/22
Project: Standard

Manganese Catalysed Enantioselective Hydrogenation of in-situ-Synthesised Imines: Efficient Asymmetric Synthesis of Amino-indane Derivatives (dataset)
Oates, C. (Contributor), Goodfellow, A. S. (Contributor), Buehl, M. (Creator) & Clarke, M. (Creator), University of St Andrews, 10 May 2023
DOI: 10.17630/cf0c7769-e031-4bb2-8d88-b1636282e4a1
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title = "Manganese catalysed enantioselective hydrogenation of in-situ-synthesised imines: efficient asymmetric synthesis of amino-indane derivatives",

abstract = "A manganese catalyst of a facially coordinating P,N,N ligand catalyses the hydrogenation of imines derived from indanone derivatives with high enantioselectivity. There is no requirement for an activating group and imines can be generated in situ. The selectivity can be rationalised by DFT calculations.",

author = "Conor Oates and Goodfellow, {Alister S.} and Michael Buehl and Clarke, {Matthew L.}",

note = "Funding: The authors would like to thank the University of St Andrews, and the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) for financial support [Ph.D. studentship to CO; Grant code: EP/L016419/1], and the EaSI-CAT programme PhD studentship to AG. They thank Solvias for the gift of chiral chemicals.",

year = "2023",

month = may,

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doi = "10.1039/D3GC00399J",

language = "English",

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T1 - Manganese catalysed enantioselective hydrogenation of in-situ-synthesised imines

T2 - efficient asymmetric synthesis of amino-indane derivatives

AU - Oates, Conor

AU - Goodfellow, Alister S.

AU - Buehl, Michael

AU - Clarke, Matthew L.

N1 - Funding: The authors would like to thank the University of St Andrews, and the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) for financial support [Ph.D. studentship to CO; Grant code: EP/L016419/1], and the EaSI-CAT programme PhD studentship to AG. They thank Solvias for the gift of chiral chemicals.

PY - 2023/5/21

Y1 - 2023/5/21

N2 - A manganese catalyst of a facially coordinating P,N,N ligand catalyses the hydrogenation of imines derived from indanone derivatives with high enantioselectivity. There is no requirement for an activating group and imines can be generated in situ. The selectivity can be rationalised by DFT calculations.

AB - A manganese catalyst of a facially coordinating P,N,N ligand catalyses the hydrogenation of imines derived from indanone derivatives with high enantioselectivity. There is no requirement for an activating group and imines can be generated in situ. The selectivity can be rationalised by DFT calculations.

U2 - 10.1039/D3GC00399J

DO - 10.1039/D3GC00399J

M3 - Article

SN - 1463-9262

VL - 25

SP - 3864

EP - 3868

JO - Green Chemistry

JF - Green Chemistry

IS - 10

ER -

Manganese catalysed enantioselective hydrogenation of in-situ-synthesised imines: efficient asymmetric synthesis of amino-indane derivatives

Abstract

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Projects

CRITICAT - EASiCAT Studentship: CRITICAT - EASiCAT Studentship

Datasets

Manganese Catalysed Enantioselective Hydrogenation of in-situ-Synthesised Imines: Efficient Asymmetric Synthesis of Amino-indane Derivatives (dataset)

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