Magnesium deficiency and cardiometabolic disease

Remi Fritzen; Amy Davies; Miriam Veenhuizen; Matthew Campbell; Samantha J. Pitt; Ramzi A. Ajjan; Alan J. Stewart

doi:10.3390/nu15102355

Magnesium deficiency and cardiometabolic disease

Remi Fritzen, Amy Davies, Miriam Veenhuizen, Matthew Campbell, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

8 Downloads (Pure)

Abstract

Magnesium (Mg²⁺) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg²⁺ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg²⁺ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg²⁺ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.

Original language	English
Article number	2355
Number of pages	19
Journal	Nutrients
Volume	15
Issue number	10
DOIs	https://doi.org/10.3390/nu15102355
Publication status	Published - 17 May 2023

Keywords

Cardiovascular disease
Magnesium
Metal ion dyshomeostasis
Nutrient deficiency
Supplementation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/nu15102355Licence: CC BY

Nutrients_15_2355
Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 986 KBLicence: CC BY

Bilateral BBSRC-FAPESP: Bilateral BBSRC-FAPESP: A "speciomic" toolkit to investigate fatty acid-mediated changes in plasma zinc speciation and their physiological effects
Stewart, A. J. (PI)
BBSRC
1/11/21 → 31/10/24
Project: Standard

Cite this

@article{13854a30c5944676bc483124cc6a9770,

title = "Magnesium deficiency and cardiometabolic disease",

abstract = "Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.",

keywords = "Cardiovascular disease, Magnesium, Metal ion dyshomeostasis, Nutrient deficiency, Supplementation",

author = "Remi Fritzen and Amy Davies and Miriam Veenhuizen and Matthew Campbell and Pitt, {Samantha J.} and Ajjan, {Ramzi A.} and Stewart, {Alan J.}",

note = "Funding: R.F. is supported by the Biological and Biotechnological Sciences Research Council.",

year = "2023",

month = may,

day = "17",

doi = "10.3390/nu15102355",

language = "English",

volume = "15",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

}

TY - JOUR

T1 - Magnesium deficiency and cardiometabolic disease

AU - Fritzen, Remi

AU - Davies, Amy

AU - Veenhuizen, Miriam

AU - Campbell, Matthew

AU - Pitt, Samantha J.

AU - Ajjan, Ramzi A.

AU - Stewart, Alan J.

N1 - Funding: R.F. is supported by the Biological and Biotechnological Sciences Research Council.

PY - 2023/5/17

Y1 - 2023/5/17

N2 - Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.

AB - Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.

KW - Cardiovascular disease

KW - Magnesium

KW - Metal ion dyshomeostasis

KW - Nutrient deficiency

KW - Supplementation

U2 - 10.3390/nu15102355

DO - 10.3390/nu15102355

M3 - Review article

SN - 2072-6643

VL - 15

JO - Nutrients

JF - Nutrients

IS - 10

M1 - 2355

ER -

Magnesium deficiency and cardiometabolic disease

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Projects

Bilateral BBSRC-FAPESP: Bilateral BBSRC-FAPESP: A "speciomic" toolkit to investigate fatty acid-mediated changes in plasma zinc speciation and their physiological effects

Cite this