Long-term whole blood DNA preservation by cost-efficient cryosilicification

Liang Zhou, Qi Lei, Jimin Guo, Yuanyuan Gao, Jianjun Shi, Hong Yu, Wenxiang Yin, Jiangfan Cao, Botao Xiao, Jacopo Andreo, Romy Ettlinger, C Jeffrey Brinker, Stefan Wuttke*, Wei Zhu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
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Deoxyribonucleic acid (DNA) is the blueprint of life, and cost-effective methods for its long-term storage could have many potential benefits to society. Here we present the method of in situ cryosilicification of whole blood cells, which allows long-term preservation of DNA. Importantly, our straightforward approach is inexpensive, reliable, and yields cryosilicified samples that fulfill the essential criteria for safe, long-term DNA preservation, namely robustness against external stressors, such as radical oxygen species or ultraviolet radiation, and long-term stability in humid conditions at elevated temperatures. Our approach could enable the room temperature storage of genomic information in book-size format for more than one thousand years (thermally equivalent), costing only 0.5 $/person. Additionally, our demonstration of 3D-printed DNA banking artefacts, could potentially allow 'artificial fossilization'.
Original languageEnglish
Article number6265
Number of pages14
JournalNature Communications
Publication statusPublished - 21 Oct 2022


  • Preservation, Biological - methods
  • Blood Preservation - methods
  • Oxygen
  • Ultraviolet Rays
  • DNA - genetics
  • Humans


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