Abstract
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino) but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and >98% e.e.
Original language | English |
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Pages (from-to) | 2664-2666 |
Number of pages | 3 |
Journal | Chemical Communications |
Issue number | 25 |
DOIs | |
Publication status | Published - 2006 |
Keywords
- 1,3-DIPOLAR CYCLOADDITION
- GLYCOSIDASE INHIBITORS
- AMMONIA EQUIVALENTS
- KINETIC PROTONATION
- ACIDS
- STEREOCHEMISTRY
- DERIVATIVES
- AGENTS