Lipid metabolism in Trypanosoma brucei

Terry K Smith, Peter Buetikofer

Research output: Contribution to journalReview articlepeer-review

83 Citations (Scopus)

Abstract

Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites. (C) 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)66-79
Number of pages14
JournalMolecular and Biochemical Parasitology
Volume172
Issue number2
DOIs
Publication statusPublished - 3 Aug 2010

Keywords

  • Trypanosoma
  • Phospholipids
  • Sphingolipids
  • Fatty acids
  • Biosynthesis
  • Metabolism
  • Gene IDs
  • VARIANT SURFACE GLYCOPROTEIN
  • FATTY-ACID SYNTHESIS
  • BLOOD-STREAM-FORM
  • DE-N-ACETYLASE
  • AFRICAN SLEEPING SICKNESS
  • GLYCOSYL PHOSPHATIDYLINOSITOL MYRISTOYLATION
  • INOSITOL PHOSPHORYLCERAMIDE SYNTHASE
  • GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS
  • LEISHMANIA-DONOVANI
  • SPHINGOLIPID SYNTHESIS

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