Lipid metabolism in Trypanosoma brucei

Terry K Smith; Peter Buetikofer

doi:10.1016/j.molbiopara.2010.04.001

Lipid metabolism in Trypanosoma brucei

Research output: Contribution to journal › Review article › peer-review

Abstract

Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites. (C) 2010 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	66-79
Number of pages	14
Journal	Molecular and Biochemical Parasitology
Volume	172
Issue number	2
DOIs	https://doi.org/10.1016/j.molbiopara.2010.04.001
Publication status	Published - 3 Aug 2010

Keywords

Trypanosoma
Phospholipids
Sphingolipids
Fatty acids
Biosynthesis
Metabolism
Gene IDs
VARIANT SURFACE GLYCOPROTEIN
FATTY-ACID SYNTHESIS
BLOOD-STREAM-FORM
DE-N-ACETYLASE
AFRICAN SLEEPING SICKNESS
GLYCOSYL PHOSPHATIDYLINOSITOL MYRISTOYLATION
INOSITOL PHOSPHORYLCERAMIDE SYNTHASE
GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS
LEISHMANIA-DONOVANI
SPHINGOLIPID SYNTHESIS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.molbiopara.2010.04.001

Cite this

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title = "Lipid metabolism in Trypanosoma brucei",

abstract = "Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites. (C) 2010 Elsevier B.V. All rights reserved.",

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author = "Smith, {Terry K} and Peter Buetikofer",

year = "2010",

month = aug,

day = "3",

doi = "10.1016/j.molbiopara.2010.04.001",

language = "English",

volume = "172",

pages = "66--79",

journal = "Molecular and Biochemical Parasitology",

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TY - JOUR

T1 - Lipid metabolism in Trypanosoma brucei

AU - Smith, Terry K

AU - Buetikofer, Peter

PY - 2010/8/3

Y1 - 2010/8/3

N2 - Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites. (C) 2010 Elsevier B.V. All rights reserved.

AB - Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites. (C) 2010 Elsevier B.V. All rights reserved.

KW - Trypanosoma

KW - Phospholipids

KW - Sphingolipids

KW - Fatty acids

KW - Biosynthesis

KW - Metabolism

KW - Gene IDs

KW - VARIANT SURFACE GLYCOPROTEIN

KW - FATTY-ACID SYNTHESIS

KW - BLOOD-STREAM-FORM

KW - DE-N-ACETYLASE

KW - AFRICAN SLEEPING SICKNESS

KW - GLYCOSYL PHOSPHATIDYLINOSITOL MYRISTOYLATION

KW - INOSITOL PHOSPHORYLCERAMIDE SYNTHASE

KW - GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS

KW - LEISHMANIA-DONOVANI

KW - SPHINGOLIPID SYNTHESIS

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U2 - 10.1016/j.molbiopara.2010.04.001

DO - 10.1016/j.molbiopara.2010.04.001

M3 - Review article

SN - 0166-6851

VL - 172

SP - 66

EP - 79

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

IS - 2

ER -

Lipid metabolism in Trypanosoma brucei

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

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Validating choline metabolism WT: validating choline metabolism as a drug target in the fight against T Brucei

Cite this

Lipid metabolism in Trypanosoma brucei

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

Validating choline metabolism WT: validating choline metabolism as a drug target in the fight against T Brucei

Cite this