Projects per year
Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites. (C) 2010 Elsevier B.V. All rights reserved.
- Fatty acids
- Gene IDs
- VARIANT SURFACE GLYCOPROTEIN
- FATTY-ACID SYNTHESIS
- AFRICAN SLEEPING SICKNESS
- GLYCOSYL PHOSPHATIDYLINOSITOL MYRISTOYLATION
- INOSITOL PHOSPHORYLCERAMIDE SYNTHASE
- GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS
- SPHINGOLIPID SYNTHESIS
FingerprintDive into the research topics of 'Lipid metabolism in Trypanosoma brucei'. Together they form a unique fingerprint.
- 1 Finished
Validating choline metabolism WT: validating choline metabolism as a drug target in the fight against T Brucei
1/12/09 → 30/11/11