Projects per year
Abstract
The discovery of a copper precatalyst that facilitates the key mechanistic steps of arene halodeboronation has allowed a step change in the synthesis of radioiodine-containing arenes. The active precatalyst [Cu(OAc)(phen)2]OAc was shown to perform room temperature radio-iododeboronation of aryl boronic acids with 1–2 mol % loadings and 10 min reaction times. These mild conditions enable particularly clean reactions, as demonstrated with the efficient preparation of the radiopharmaceutical and SPECT tracer, meta-iodobenzylguanidine (MIBG).
Original language | English |
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Number of pages | 5 |
Journal | Organic Letters |
Volume | Ahead of Print |
Early online date | 9 Feb 2024 |
DOIs | |
Publication status | E-pub ahead of print - 9 Feb 2024 |
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Dive into the research topics of 'Ligand-enabled copper-mediated radioiodination of arenes'. Together they form a unique fingerprint.-
Allan Watson Programme Grant: Boron: Beyond the Reagent
Watson, A. J. B. (PI), Morris, R. E. (CoI), Smith, A. D. (CoI) & Zysman-Colman, E. (CoI)
1/05/23 → 30/04/28
Project: Standard
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A biochemical boron tagging stategy: A biochemical boron tagging strategy for biomolecule visualisation and profiling
Watson, A. J. B. (PI)
1/09/22 → 31/08/24
Project: Fellowship
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Accessing Pharmacophoric Space: Accessing Pharmacophoric Space Via Asymmetric Protonation
Watson, A. J. B. (PI)
1/10/19 → 30/09/22
Project: Standard