Abstract
The following are the proceedings of a symposium held at the Second International Congress for Respiratory Science in Bad Honnef, Germany The goals of the symposium were to delineate the blood-gas barrier phenotype across vertebrate species, to delineate the interrelationship between the evolution of the blood-gas barrier, locomotion and metabolism: to introduce the selection pressures for the evolution of the surfactant system as a key to understanding the physiology of the blood-gas barrier, to introduce the lung lipofibroblast and its product. leptin, which coordinately regulates pulmonary surfactant, type IV collagen in the basement membrane and host defense, as the cell-molecular site of selection pressure for the blood-gas barrier, to drill down to the gene regulatory network(s) involved in leptin signaling and the blood-gas barrier phenotype, to extend the relationship between leptin and the blood-gas barrier to diving mammals. (C) 2010 Elsevier B.V All rights reserved
| Original language | English |
|---|---|
| Pages (from-to) | 37-42 |
| Number of pages | 6 |
| Journal | Respiratory Physiology & Neurobiology |
| Volume | 173 |
| DOIs | |
| Publication status | Published - 31 Aug 2010 |
Keywords
- Evolution of the blood-gas barrier, structure and function of the blood-gas barrier
- Constraints on the blood-gas barrier
- The surfactant system and evolution of the blood-gas barrier
- Leptin and the evolution of the blood-gas barrier
- Leptin signaling, the epidermal growth factor pathway, and formation and homeostatic regulation of the blood-gas barrier
- Evolution of the blood-gas barrier in diving mammals
- MARSUPIAL SMINTHOPSIS-CRASSICAUDATA
- PULMONARY SURFACTANT SYSTEM
- GOULDS WATTLED BAT
- DIVING MAMMALS
- MARINE MAMMALS
- LUNG DEVELOPMENT
- RAPID AROUSAL
- PHYSIOLOGY
- TORPOR
- STIMULATION
