Language and reading impairments are associated with increased prevalence of non-right handedness

Filippo Abbondanza; Philip S. Dale; Carol A. Wang; Marianna E. Hayiou-Thomas; Umar Toseeb; Tanner S Koomar; Karen G Wigg; Yu Feng; Kaitlyn M Price; Elizabeth N Kerr; Sharon L Guger; Maureen W Lovett; Lisa J Strug; Elsje van Bergen; Conor V. Dolan; J Bruce Tomblin; Kristina Moll; Gerd Schulte-Körne; Nina Neuhoff; Andreas Warnke; Simon E. Fisher; Cathy L Barr; Jacob J Michaelson; Dorret I. Boomsma; Margaret J. Snowling; Charles  Hulme; Andrews J.O. Whitehouse; Craig E Pennell; Dianne F. Newbury; John Stein; Joel B. Talcott; Dorothy V.M. Bishop; Silvia Paracchini

doi:10.1111/cdev.13914

Language and reading impairments are associated with increased prevalence of non-right handedness

Filippo Abbondanza
, Philip S. Dale
, Carol A. Wang
, Marianna E. Hayiou-Thomas
, Umar Toseeb
, Tanner S Koomar
, Karen G Wigg
, Yu Feng
, Kaitlyn M Price
, Elizabeth N Kerr
, Sharon L Guger
, Maureen W Lovett
, Lisa J Strug
, Elsje van Bergen
, Conor V. Dolan
, J Bruce Tomblin
, Kristina Moll
, Gerd Schulte-Körne
, Nina Neuhoff
, Andreas Warnke

Simon E. Fisher, Cathy L Barr, Jacob J Michaelson, Dorret I. Boomsma, Margaret J. Snowling, Charles Hulme, Andrews J.O. Whitehouse, Craig E Pennell, Dianne F. Newbury, John Stein, Joel B. Talcott, Dorothy V.M. Bishop, Silvia Paracchini^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (N_cases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.

Original language	English
Pages (from-to)	970-984
Number of pages	15
Journal	Child Development
Volume	94
Issue number	4
Early online date	13 Feb 2023
DOIs	https://doi.org/10.1111/cdev.13914
Publication status	Published - 22 Jun 2023

Keywords

Handedness
Reading
Language
Cognitive abilities
Meta-analysis
Neurodevelopment
ALSPAC

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10.1111/cdev.13914Licence: CC BY

Abbondanza_2023_CD_Language-reading_CC
Copyright © 2023 The Authors. Child Development published by Wiley Periodicals LLC on behalf of Society for Research in Child Development. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Dr Silvia Paracchini - Public Enhancemen: Is there a link between asymmetries and congnition
Paracchini, S. (PI)
The Royal Society
27/05/18 → 26/05/22
Project: Standard

Language and reading impairments are associated with increased prevalence of non-right handedness (dataset)
Paracchini, S. (Creator), GitHub, 2022
https://github.com/fabbondanza/GenLang_hand_preference_meta_analysis
Dataset

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Abbondanza, F., Dale, P. S., Wang, C. A., Hayiou-Thomas, M. E., Toseeb, U., Koomar, T. S., Wigg, K. G., Feng, Y., Price, K. M., Kerr, E. N., Guger, S. L., Lovett, M. W., Strug, L. J., van Bergen, E., Dolan, C. V., Tomblin, J. B., Moll, K., Schulte-Körne, G., Neuhoff, N., ... Paracchini, S. (2023). Language and reading impairments are associated with increased prevalence of non-right handedness. Child Development, 94(4), 970-984. https://doi.org/10.1111/cdev.13914

@article{6b0c1b1043294358933398c58fd05bdf,

title = "Language and reading impairments are associated with increased prevalence of non-right handedness",

abstract = "Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (Ncases = 1994) showed elevated NRH \% in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.",

keywords = "Handedness, Reading, Language, Cognitive abilities, Meta-analysis, Neurodevelopment, ALSPAC",

author = "Filippo Abbondanza and Dale, \{Philip S.\} and Wang, \{Carol A.\} and Hayiou-Thomas, \{Marianna E.\} and Umar Toseeb and Koomar, \{Tanner S\} and Wigg, \{Karen G\} and Yu Feng and Price, \{Kaitlyn M\} and Kerr, \{Elizabeth N\} and Guger, \{Sharon L\} and Lovett, \{Maureen W\} and Strug, \{Lisa J\} and \{van Bergen\}, Elsje and Dolan, \{Conor V.\} and Tomblin, \{J Bruce\} and Kristina Moll and Gerd Schulte-K{\"o}rne and Nina Neuhoff and Andreas Warnke and Fisher, \{Simon E.\} and Barr, \{Cathy L\} and Michaelson, \{Jacob J\} and Boomsma, \{Dorret I.\} and Snowling, \{Margaret J.\} and Charles Hulme and Whitehouse, \{Andrews J.O.\} and Pennell, \{Craig E\} and Newbury, \{Dianne F.\} and John Stein and Talcott, \{Joel B.\} and Bishop, \{Dorothy V.M.\} and Silvia Paracchini",

note = "Funding: Royal Society - UF150663, RGF\textbackslash{}EA\textbackslash{}180141; Wellcome Trust - 217065/Z/19/Z; H2020 European Research Council - 694189; NWO - 451-15-017; National Health and Medical Research Council - 1173896; Canadian Institute for Health Research - MOP-133440.",

year = "2023",

month = jun,

day = "22",

doi = "10.1111/cdev.13914",

language = "English",

volume = "94",

pages = "970--984",

journal = "Child Development",

issn = "0009-3920",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

Abbondanza, F, Dale, PS, Wang, CA, Hayiou-Thomas, ME, Toseeb, U, Koomar, TS, Wigg, KG, Feng, Y, Price, KM, Kerr, EN, Guger, SL, Lovett, MW, Strug, LJ, van Bergen, E, Dolan, CV, Tomblin, JB, Moll, K, Schulte-Körne, G, Neuhoff, N, Warnke, A, Fisher, SE, Barr, CL, Michaelson, JJ, Boomsma, DI, Snowling, MJ, Hulme, C, Whitehouse, AJO, Pennell, CE, Newbury, DF, Stein, J, Talcott, JB, Bishop, DVM & Paracchini, S 2023, 'Language and reading impairments are associated with increased prevalence of non-right handedness', Child Development, vol. 94, no. 4, pp. 970-984. https://doi.org/10.1111/cdev.13914

TY - JOUR

T1 - Language and reading impairments are associated with increased prevalence of non-right handedness

AU - Abbondanza, Filippo

AU - Dale, Philip S.

AU - Wang, Carol A.

AU - Hayiou-Thomas, Marianna E.

AU - Toseeb, Umar

AU - Koomar, Tanner S

AU - Wigg, Karen G

AU - Feng, Yu

AU - Price, Kaitlyn M

AU - Kerr, Elizabeth N

AU - Guger, Sharon L

AU - Lovett, Maureen W

AU - Strug, Lisa J

AU - van Bergen, Elsje

AU - Dolan, Conor V.

AU - Tomblin, J Bruce

AU - Moll, Kristina

AU - Schulte-Körne, Gerd

AU - Neuhoff, Nina

AU - Warnke, Andreas

AU - Fisher, Simon E.

AU - Barr, Cathy L

AU - Michaelson, Jacob J

AU - Boomsma, Dorret I.

AU - Snowling, Margaret J.

AU - Hulme, Charles

AU - Whitehouse, Andrews J.O.

AU - Pennell, Craig E

AU - Newbury, Dianne F.

AU - Stein, John

AU - Talcott, Joel B.

AU - Bishop, Dorothy V.M.

AU - Paracchini, Silvia

N1 - Funding: Royal Society - UF150663, RGF\EA\180141; Wellcome Trust - 217065/Z/19/Z; H2020 European Research Council - 694189; NWO - 451-15-017; National Health and Medical Research Council - 1173896; Canadian Institute for Health Research - MOP-133440.

PY - 2023/6/22

Y1 - 2023/6/22

N2 - Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.

AB - Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.

KW - Handedness

KW - Reading

KW - Language

KW - Cognitive abilities

KW - Meta-analysis

KW - Neurodevelopment

KW - ALSPAC

U2 - 10.1111/cdev.13914

DO - 10.1111/cdev.13914

M3 - Article

C2 - 36780127

SN - 0009-3920

VL - 94

SP - 970

EP - 984

JO - Child Development

JF - Child Development

IS - 4

ER -

Language and reading impairments are associated with increased prevalence of non-right handedness

Abstract

Keywords

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Dr Silvia Paracchini - Public Enhancemen: Is there a link between asymmetries and congnition

Datasets

Language and reading impairments are associated with increased prevalence of non-right handedness (dataset)

Cite this