Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

Kerry A Pettigrew; Samuelle F Fajutrao Valles; Kristina Moll; Kate Northstone; Susan Ring; Craig Pennell; Carol Wang; Ruth Leavett; Marianna E Hayiou-Thomas; Paul Thompson; Nuala H Simpson; Simon E Fisher; Andrew J O Whitehouse; Margaret J Snowling; Dianne F Newbury; Silvia Paracchini; SLI Consortium

doi:10.1111/gbb.12213

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

Kerry A Pettigrew, Samuelle F Fajutrao Valles, Kristina Moll, Kate Northstone, Susan Ring, Craig Pennell, Carol Wang, Ruth Leavett, Marianna E Hayiou-Thomas, Paul Thompson, Nuala H Simpson, Simon E Fisher, Andrew J O Whitehouse, Margaret J Snowling, Dianne F Newbury, Silvia Paracchini, SLI Consortium

Research output: Contribution to journal › Article › peer-review

Abstract

Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

Original language	English
Pages (from-to)	369-376
Journal	Genes, Brain and Behavior
Volume	14
Issue number	4
Early online date	16 Mar 2015
DOIs	https://doi.org/10.1111/gbb.12213
Publication status	Published - 23 Apr 2015

Keywords

Dyscalculia
Dyslexia
Genetic association
Cognitive abilities
Neurodevelopmental disorders
ALSPAC

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10.1111/gbb.12213

Pettigrew_et_al-2015-Genes,_Brain_and_Behavior
© 2015 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 261 KB

Institutional Strategic Support Fund: Insitutional Stratigic Support Fund (ISSF)
Naismith, J. (PI)
The Wellcome Trust
1/03/12 → 28/02/15
Project: Standard

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Pettigrew, K. A., Fajutrao Valles, S. F., Moll, K., Northstone, K., Ring, S., Pennell, C., Wang, C., Leavett, R., Hayiou-Thomas, M. E., Thompson, P., Simpson, N. H., Fisher, S. E., Whitehouse, A. J. O., Snowling, M. J., Newbury, D. F., Paracchini, S., & SLI Consortium (2015). Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. Genes, Brain and Behavior, 14(4), 369-376. https://doi.org/10.1111/gbb.12213

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title = "Lack of replication for the myosin-18B association with mathematical ability in independent cohorts",

abstract = "Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.",

keywords = "Dyscalculia, Dyslexia, Genetic association, Cognitive abilities, Neurodevelopmental disorders, ALSPAC",

author = "Pettigrew, {Kerry A} and {Fajutrao Valles}, {Samuelle F} and Kristina Moll and Kate Northstone and Susan Ring and Craig Pennell and Carol Wang and Ruth Leavett and Hayiou-Thomas, {Marianna E} and Paul Thompson and Simpson, {Nuala H} and Fisher, {Simon E} and Whitehouse, {Andrew J O} and Snowling, {Margaret J} and Newbury, {Dianne F} and Silvia Paracchini and {SLI Consortium}",

note = "SP is a Royal Society University Research Fellow. This specific study in the ALSPAC cohort was supported by a MRC grant to SP [grant number G0800523/8647]. Support to the analysis was provided by the St Andrews Bioinformatics Unit funded by the Wellcome Trust [grant 097831/Z/11/Z]. ",

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month = apr,

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doi = "10.1111/gbb.12213",

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Pettigrew, KA, Fajutrao Valles, SF, Moll, K, Northstone, K, Ring, S, Pennell, C, Wang, C, Leavett, R, Hayiou-Thomas, ME, Thompson, P, Simpson, NH, Fisher, SE, Whitehouse, AJO, Snowling, MJ, Newbury, DF, Paracchini, S & SLI Consortium 2015, 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts', Genes, Brain and Behavior, vol. 14, no. 4, pp. 369-376. https://doi.org/10.1111/gbb.12213

TY - JOUR

T1 - Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

AU - Pettigrew, Kerry A

AU - Fajutrao Valles, Samuelle F

AU - Moll, Kristina

AU - Northstone, Kate

AU - Ring, Susan

AU - Pennell, Craig

AU - Wang, Carol

AU - Leavett, Ruth

AU - Hayiou-Thomas, Marianna E

AU - Thompson, Paul

AU - Simpson, Nuala H

AU - Fisher, Simon E

AU - Whitehouse, Andrew J O

AU - Snowling, Margaret J

AU - Newbury, Dianne F

AU - Paracchini, Silvia

AU - SLI Consortium

N1 - SP is a Royal Society University Research Fellow. This specific study in the ALSPAC cohort was supported by a MRC grant to SP [grant number G0800523/8647]. Support to the analysis was provided by the St Andrews Bioinformatics Unit funded by the Wellcome Trust [grant 097831/Z/11/Z].

PY - 2015/4/23

Y1 - 2015/4/23

N2 - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

AB - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

KW - Dyscalculia

KW - Dyslexia

KW - Genetic association

KW - Cognitive abilities

KW - Neurodevelopmental disorders

KW - ALSPAC

U2 - 10.1111/gbb.12213

DO - 10.1111/gbb.12213

M3 - Article

C2 - 25778778

SN - 1601-1848

VL - 14

SP - 369

EP - 376

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

IS - 4

ER -

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

Abstract

Keywords

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Institutional Strategic Support Fund: Insitutional Stratigic Support Fund (ISSF)

Cite this