Kinetic resolution and parallel kinetic resolution of methyl (±)-5-alkyl-cyclopentene-l-carboxylates for the asymmetric synthesis of 5-alkyl-cispentacin derivatives

Stephen G. Davies*, A. Christopher Garner, Marcus J.C. Long, Rachel M. Morrison, Paul M. Roberts, Edward D. Savory, Andrew D. Smith, Miles J. Sweet, Jonathan M. Withey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Conjugate addition of lithium dibenzylamide to methyl 5-isopropyl, 5-phenyl- and 5-tert-butyl-cyclopentene-1-carboxylates occurs with high levels of substrate control (>88% de), with preferential addition to the face of the cyclic α,β-unsaturated acceptor anti- to the stereodirecting 5-alkyl substituent. Treatment of a range of methyl (±)-5-alkyl-cyclopentene-1- carboxylates with both lithium (±)-N-benzyl-N-α-methylbenzylamide and lithium (±)-N-3,4-dimethoxybenzyl-N-α-methylbenzylamide indicates significant enantiorecognition in their mutual kinetic resolutions, with preferential addition anti- to the 5-alkyl substituent, giving the 1,2-syn-1,5-anti-arrangement (E > 16) after enolate protonation anti- to the amino functionality. The kinetic resolution of a range of methyl (±)-5-alkyl-cyclopentene-1-carboxylates with lithium (S)-N-benzyl-N- α-methylbenzylamide, and their efficient parallel kinetic resolution with a pseudoenantiomeric mixture of lithium (S)-N-benzyl-N-α-methylbenzylamide and lithium (R)-N-3,4-dimethoxybenzyl-N-α-methylbenzylamide are also demonstrated, giving a range of 5-alkyl-cispentacin derivatives in >98% de and high ee after N-deprotection.

Original languageEnglish
Pages (from-to)2762-2775
Number of pages14
JournalOrganic and Biomolecular Chemistry
Volume3
Issue number15
DOIs
Publication statusPublished - 7 Aug 2005

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