Abstract
A synthetic route to isotopically labelled forms of the tropane alkaloid hyoscyamine, including (RS)-[3',3',-H-2(2)]- (2a) and (RS)-[1'-C-13,3',3',-H-2(2)]- (2b) hyoscyamines, involving the reaction between phenylacetyl tropine and formaldehyde is described. The isotopically labelled products enable the metabolism of hyoscyamine to be studied in plants such as Datura stramonium. Copyright (C) 2002 John Wiley Sons, Ltd.
Original language | English |
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Pages (from-to) | 191-198 |
Number of pages | 8 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 45 |
DOIs | |
Publication status | Published - 15 Mar 2002 |
Keywords
- tropane alkaloids
- tropic acid
- hyoscyamine
- Datura stramonium
- biosynthesis
- TROPIC ACID
- DATURA-STRAMONIUM
- STEREOCHEMICAL COURSE
- BIOSYNTHESIS
- REARRANGEMENT
- HYOSCYAMINE
- PHENYLLACTATE
- PHENYLALANINE
- LITTORINE