Abstract
Screening of a range of chiral isothioureas and acyl donors to promote the asymmetric C-acylation of silyl ketene acetals indicates that C(2)-aryl-dihydro-pyrimidobenzothiazole-derived isothioureas and propionic anhydride give optimal reactivity and enantioselectivity in this process. Under optimised conditions 3-acyl-3-aryl or 3-acyl-3-alkylfuranones are prepared in good yields and moderate to excellent enantioselectivities (up to 98% ee; ee = enantiomeric excess).
Original language | English |
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Pages (from-to) | 11060-11067 |
Number of pages | 8 |
Journal | Chemistry - A European Journal |
Volume | 17 |
Issue number | 39 |
DOIs | |
Publication status | Published - Sept 2011 |