Isomerization, autoxidation and epimerization for the introduction of C-1 to C-5 functionality into the taxane ABC ring system

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Abstract

Treatment of 2-ketotax-3-enes with t-BuOK/t-BuOH/THF/65°C results in isomerization of the double bond into the 4,5-
position and a trans-B/C ring fusion. Subsequent exposure to t-BuOK/THF/O2/P(OEt)3 introduces the C-1-hydroxyl
group.
Original languageEnglish
JournalTetrahedron Letters
DOIs
Publication statusPublished - 1996

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