Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

Xuan Feng; Davide Bello; David O'Hagan

doi:10.1039/D1RA00235J

Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

Xuan Feng, Davide Bello, David O'Hagan

Research output: Contribution to journal › Article › peer-review

Abstract

The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.

Original language	English
Pages (from-to)	5291-5294
Number of pages	4
Journal	RSC Advances
Volume	11
Issue number	10
Early online date	28 Jan 2021
DOIs	https://doi.org/10.1039/D1RA00235J
Publication status	E-pub ahead of print - 28 Jan 2021

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10.1039/D1RA00235JLicence: CC BY-NC

Feng_2021_RSCadv_Isolation_CC
Copyright © 2021 The Author(s). Open Access article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Final published version, 718 KBLicence: CC BY-NC

Partially fluorinated alkyl motifs: Partially fluorinated alkyl motifs for pharmaceuticals and agrochemicals research
O'Hagan, D. (PI)
EPSRC
7/04/18 → 15/07/21
Project: Standard

Cite this

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title = "Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus",

abstract = "The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.",

author = "Xuan Feng and Davide Bello and David O'Hagan",

note = "Funding: We thank EPSRC (EP/R013799/1) for a grant (DB) and the University of St Andrews for a Studentship (XF).",

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AU - Feng, Xuan

AU - Bello, Davide

AU - O'Hagan, David

N1 - Funding: We thank EPSRC (EP/R013799/1) for a grant (DB) and the University of St Andrews for a Studentship (XF).

PY - 2021/1/28

Y1 - 2021/1/28

N2 - The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.

AB - The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.

U2 - 10.1039/D1RA00235J

DO - 10.1039/D1RA00235J

M3 - Article

SN - 2046-2069

VL - 11

SP - 5291

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JO - RSC Advances

JF - RSC Advances

IS - 10

ER -

Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

Abstract

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Partially fluorinated alkyl motifs: Partially fluorinated alkyl motifs for pharmaceuticals and agrochemicals research

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