Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes

Z. Wang; P. André; D. McLean; S.I. Brown; G.J. Florence; A. Cuschieri

doi:10.1016/j.medengphy.2014.07.013

Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes

Z. Wang, P. André, D. McLean, S.I. Brown, G.J. Florence, A. Cuschieri

Research output: Contribution to journal › Article › peer-review

Abstract

Feasibility studies are needed to demonstrate that safe and effective manipulation of bowel during Minimal Access Surgery (MAS) can be obtained by use of magnetic force. This paper characterises two classes of magnetic particles: stainless steel microparticles (SS-μPs) and iron oxide nanoparticles (IO-nPs) in terms of their magnetisation, chemical composition, crystallinity, morphology and size distribution. Both magnetic particles were dispersed in a high viscosity biological liquid for intraluminal injection of bowel. Ex vivo porcine bowel segments were then retracted by permanent magnetic probes of 5.0 and 10 mm diameter. Strong retraction forces reaching 6 N maximum were obtained by magnetic fluid based on dispersion of SS-μPs. In contrast, the IO-nP-based magnetic liquid generated less attraction force, due to both lower magnetic and solution properties of the IO-nPs. The comparison of the two particles allowed the identification of the rules to engineer the next generation of particles. The results with SS-μPs provide proof on concept that intraluminal injection of magnetic fluid can generate sufficient force for efficient bowel retraction. Thereafter we shall carry out in vivo animal studies for efficacy and safety of both types of ferrofluids.

Original language	English
Pages (from-to)	1521-1525
Number of pages	5
Journal	Medical Engineering and Physics
Volume	36
Issue number	11
Early online date	26 Aug 2014
DOIs	https://doi.org/10.1016/j.medengphy.2014.07.013
Publication status	Published - Nov 2014

Keywords

Characterisation
Magnetic particles
Physical properties
Magnetic bowel retraction
Minimal access surgery (MAS)

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10.1016/j.medengphy.2014.07.013

MEP-D-13-00465R2 - accepted-cleanversion
NOTICE: this is the author’s version of a work that was accepted for publication in Medical Engineering & Physics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Medical Engineering & Physics, 36(11), 2014. doi:10.1016/j.medengphy.2014.07.013
Accepted author manuscript, 707 KB

Impact Acceleration Account: Impact Acceleration Account
Woollins, J. D. (PI)
EPSRC
1/10/15 → 31/03/17
Project: Standard
Biomagnetic retraction for endoscopic: Biomagnetic retraction for endoscopic surgery
Florence, G. J. (PI)
EPSRC
12/10/09 → 30/10/13
Project: Standard

Cite this

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title = "Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes",

abstract = "Feasibility studies are needed to demonstrate that safe and effective manipulation of bowel during Minimal Access Surgery (MAS) can be obtained by use of magnetic force. This paper characterises two classes of magnetic particles: stainless steel microparticles (SS-μPs) and iron oxide nanoparticles (IO-nPs) in terms of their magnetisation, chemical composition, crystallinity, morphology and size distribution. Both magnetic particles were dispersed in a high viscosity biological liquid for intraluminal injection of bowel. Ex vivo porcine bowel segments were then retracted by permanent magnetic probes of 5.0 and 10 mm diameter. Strong retraction forces reaching 6 N maximum were obtained by magnetic fluid based on dispersion of SS-μPs. In contrast, the IO-nP-based magnetic liquid generated less attraction force, due to both lower magnetic and solution properties of the IO-nPs. The comparison of the two particles allowed the identification of the rules to engineer the next generation of particles. The results with SS-μPs provide proof on concept that intraluminal injection of magnetic fluid can generate sufficient force for efficient bowel retraction. Thereafter we shall carry out in vivo animal studies for efficacy and safety of both types of ferrofluids.",

keywords = "Characterisation, Magnetic particles, Physical properties, Magnetic bowel retraction, Minimal access surgery (MAS)",

author = "Z. Wang and P. Andr{\'e} and D. McLean and S.I. Brown and G.J. Florence and A. Cuschieri",

note = "This work has been financially supported by the Engineering and Physical Sciences Research Council (EPSRC), UK, under Grant EP/HO 10033/1.",

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doi = "10.1016/j.medengphy.2014.07.013",

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AU - Wang, Z.

AU - André, P.

AU - McLean, D.

AU - Brown, S.I.

AU - Florence, G.J.

AU - Cuschieri, A.

N1 - This work has been financially supported by the Engineering and Physical Sciences Research Council (EPSRC), UK, under Grant EP/HO 10033/1.

PY - 2014/11

Y1 - 2014/11

N2 - Feasibility studies are needed to demonstrate that safe and effective manipulation of bowel during Minimal Access Surgery (MAS) can be obtained by use of magnetic force. This paper characterises two classes of magnetic particles: stainless steel microparticles (SS-μPs) and iron oxide nanoparticles (IO-nPs) in terms of their magnetisation, chemical composition, crystallinity, morphology and size distribution. Both magnetic particles were dispersed in a high viscosity biological liquid for intraluminal injection of bowel. Ex vivo porcine bowel segments were then retracted by permanent magnetic probes of 5.0 and 10 mm diameter. Strong retraction forces reaching 6 N maximum were obtained by magnetic fluid based on dispersion of SS-μPs. In contrast, the IO-nP-based magnetic liquid generated less attraction force, due to both lower magnetic and solution properties of the IO-nPs. The comparison of the two particles allowed the identification of the rules to engineer the next generation of particles. The results with SS-μPs provide proof on concept that intraluminal injection of magnetic fluid can generate sufficient force for efficient bowel retraction. Thereafter we shall carry out in vivo animal studies for efficacy and safety of both types of ferrofluids.

AB - Feasibility studies are needed to demonstrate that safe and effective manipulation of bowel during Minimal Access Surgery (MAS) can be obtained by use of magnetic force. This paper characterises two classes of magnetic particles: stainless steel microparticles (SS-μPs) and iron oxide nanoparticles (IO-nPs) in terms of their magnetisation, chemical composition, crystallinity, morphology and size distribution. Both magnetic particles were dispersed in a high viscosity biological liquid for intraluminal injection of bowel. Ex vivo porcine bowel segments were then retracted by permanent magnetic probes of 5.0 and 10 mm diameter. Strong retraction forces reaching 6 N maximum were obtained by magnetic fluid based on dispersion of SS-μPs. In contrast, the IO-nP-based magnetic liquid generated less attraction force, due to both lower magnetic and solution properties of the IO-nPs. The comparison of the two particles allowed the identification of the rules to engineer the next generation of particles. The results with SS-μPs provide proof on concept that intraluminal injection of magnetic fluid can generate sufficient force for efficient bowel retraction. Thereafter we shall carry out in vivo animal studies for efficacy and safety of both types of ferrofluids.

KW - Characterisation

KW - Magnetic particles

KW - Physical properties

KW - Magnetic bowel retraction

KW - Minimal access surgery (MAS)

U2 - 10.1016/j.medengphy.2014.07.013

DO - 10.1016/j.medengphy.2014.07.013

M3 - Article

SN - 1350-4533

VL - 36

SP - 1521

EP - 1525

JO - Medical Engineering and Physics

JF - Medical Engineering and Physics

IS - 11

ER -

Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes

Abstract

Keywords

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Projects

Impact Acceleration Account: Impact Acceleration Account

Biomagnetic retraction for endoscopic: Biomagnetic retraction for endoscopic surgery

Cite this