Interpreting human follicular recruitment and antimullerian hormone concentrations throughout life

Richard Fleming; Tom Kelsey; Richard Anderson; Hamish Wallace; Scott Nelson

doi:10.1016/j.fertnstert.2012.07.1114

Interpreting human follicular recruitment and antimullerian hormone concentrations throughout life

Richard Fleming, Tom Kelsey, Richard Anderson, Hamish Wallace, Scott Nelson

Research output: Contribution to journal › Article › peer-review

Abstract

The changes in the relationships between circulating antimüllerian hormone, the size of the primordial follicle pool, and follicular recruitment before and through the reproductive years have now been clarified, and show dynamic changes through sexual development. The constant relationship between the number of follicles and circulating antimüllerian hormone exists only after the age of 25 years, implying that the association between follicular recruitment and follicular survival to the later stages of development is not constant across the reproductive life course. This commentary assesses the factors that may underlie these relationships and their clinical implications for reproductive health.

Original language	English
Pages (from-to)	1097-1102
Journal	Fertility and Sterility
Volume	98
Issue number	5
DOIs	https://doi.org/10.1016/j.fertnstert.2012.07.1114
Publication status	Published - 2012

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10.1016/j.fertnstert.2012.07.1114

1 Finished

A Constraint Solver Synthesiser: A Constraint Solver Synthesiser
Miguel, I. J. (PI), Balasubramaniam, D. (CoI), Gent, I. P. (CoI), Kelsey, T. (CoI) & Linton, S. A. (CoI)
EPSRC
1/10/09 → 30/09/14
Project: Standard

3 Article
1 Review article

Can Anti-Müllerian hormone predict the diagnosis of polycystic ovary syndrome? A systematic review and meta-analysis of extracted data
Iliodromiti, S., Kelsey, T., Anderson, R. & Nelson, S., Aug 2013, In: Journal of Clinical Endocrinology & Metabolism. 98, 8, p. 3332-3340 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Data-driven assessment of the human ovarian reserve
Kelsey, T., Anderson, R. A., Wright, P., Nelson, S. M. & Wallace, W. H. B., Feb 2012, In: Molecular Human Reproduction. 18, 2, p. 79-87 9 p.
Research output: Contribution to journal › Review article › peer-review
A validated model of serum anti-Müllerian hormone from conception to menopause
Kelsey, T., Wright, P., Nelson, S., Anderson, R. & Wallace, H., 15 Jul 2011, In: PLoS ONE. 6, 7, 7 p., e22024.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Cite this

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title = "Interpreting human follicular recruitment and antimullerian hormone concentrations throughout life",

abstract = "The changes in the relationships between circulating antim{\"u}llerian hormone, the size of the primordial follicle pool, and follicular recruitment before and through the reproductive years have now been clarified, and show dynamic changes through sexual development. The constant relationship between the number of follicles and circulating antim{\"u}llerian hormone exists only after the age of 25 years, implying that the association between follicular recruitment and follicular survival to the later stages of development is not constant across the reproductive life course. This commentary assesses the factors that may underlie these relationships and their clinical implications for reproductive health.",

author = "Richard Fleming and Tom Kelsey and Richard Anderson and Hamish Wallace and Scott Nelson",

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doi = "10.1016/j.fertnstert.2012.07.1114",

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AU - Anderson, Richard

AU - Wallace, Hamish

AU - Nelson, Scott

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Y1 - 2012

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AB - The changes in the relationships between circulating antimüllerian hormone, the size of the primordial follicle pool, and follicular recruitment before and through the reproductive years have now been clarified, and show dynamic changes through sexual development. The constant relationship between the number of follicles and circulating antimüllerian hormone exists only after the age of 25 years, implying that the association between follicular recruitment and follicular survival to the later stages of development is not constant across the reproductive life course. This commentary assesses the factors that may underlie these relationships and their clinical implications for reproductive health.

U2 - 10.1016/j.fertnstert.2012.07.1114

DO - 10.1016/j.fertnstert.2012.07.1114

M3 - Article

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VL - 98

SP - 1097

EP - 1102

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 5

ER -

Interpreting human follicular recruitment and antimullerian hormone concentrations throughout life

Abstract

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Projects

A Constraint Solver Synthesiser: A Constraint Solver Synthesiser

Research output

Can Anti-Müllerian hormone predict the diagnosis of polycystic ovary syndrome? A systematic review and meta-analysis of extracted data

Data-driven assessment of the human ovarian reserve

A validated model of serum anti-Müllerian hormone from conception to menopause

Cite this