TY - JOUR
T1 - Interactions between the renin-angiotensin system and catecholamines on the cardiovascular system of elasmobranchs
AU - Tierney, ML
AU - Hamano, K
AU - Anderson, G
AU - Takei, Y
AU - Ashida, K
AU - Hazon, Neil
PY - 1997/12
Y1 - 1997/12
N2 - The interaction between homologous dogfish angiotensin II ([Asn(1), Pro(3), Ile(5)]-AngII) and catecholamines was examined using blood pressure bioassay. Both noradrenaline and [Asn(1), Pro(3), Ile(5)]-Ang II elicited a presser response. Pre-treatment with phentolamine (1 mg kg(-1)) completely abolished the noradrenaline presser response but did not alter the magnitude of the [Asn(1), Pro(3), Ile(5)]-Ang II presser response although there was an initial delay in the response to [Asn(1), Pro(3), Ile(5)]-Ang II. These results indicate that the Ang II-induced presser response is a direct Ang II-mediated vascular response in elasmobranchs.
AB - The interaction between homologous dogfish angiotensin II ([Asn(1), Pro(3), Ile(5)]-AngII) and catecholamines was examined using blood pressure bioassay. Both noradrenaline and [Asn(1), Pro(3), Ile(5)]-Ang II elicited a presser response. Pre-treatment with phentolamine (1 mg kg(-1)) completely abolished the noradrenaline presser response but did not alter the magnitude of the [Asn(1), Pro(3), Ile(5)]-Ang II presser response although there was an initial delay in the response to [Asn(1), Pro(3), Ile(5)]-Ang II. These results indicate that the Ang II-induced presser response is a direct Ang II-mediated vascular response in elasmobranchs.
KW - elasmobranch
KW - catecholamines
KW - angiotensin II
KW - cardiovascular actions
KW - CONVERTING-ENZYME-INHIBITOR
KW - FISH
UR - http://www.scopus.com/inward/record.url?scp=0001377728&partnerID=8YFLogxK
M3 - Article
SN - 0920-1742
VL - 17
SP - 333
EP - 337
JO - Fish Physiology and Biochemistry
JF - Fish Physiology and Biochemistry
ER -