Interactions between the renin-angiotensin system and catecholamines on the cardiovascular system of elasmobranchs

ML Tierney, K Hamano, G Anderson, Y Takei, K Ashida, Neil Hazon

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The interaction between homologous dogfish angiotensin II ([Asn(1), Pro(3), Ile(5)]-AngII) and catecholamines was examined using blood pressure bioassay. Both noradrenaline and [Asn(1), Pro(3), Ile(5)]-Ang II elicited a presser response. Pre-treatment with phentolamine (1 mg kg(-1)) completely abolished the noradrenaline presser response but did not alter the magnitude of the [Asn(1), Pro(3), Ile(5)]-Ang II presser response although there was an initial delay in the response to [Asn(1), Pro(3), Ile(5)]-Ang II. These results indicate that the Ang II-induced presser response is a direct Ang II-mediated vascular response in elasmobranchs.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalFish Physiology and Biochemistry
Volume17
Publication statusPublished - Dec 1997

Keywords

  • elasmobranch
  • catecholamines
  • angiotensin II
  • cardiovascular actions
  • CONVERTING-ENZYME-INHIBITOR
  • FISH

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