Insulin-like growth factor binding proteins of teleost fishes

Daniel Garcia de la Serrana, Daniel J. Macqueen

Research output: Contribution to journalReview articlepeer-review

70 Citations (Scopus)

Abstract

The insulin-like growth factor (IGF) binding protein (IGFBP) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the IGFBPs of teleost fishes, where genome duplication events have diversified gene repertoire, function and physiological regulation - with six core IGFBPs expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost IGFBP evolution, function and expression-level regulation, we highlight gaps in our understanding, and promising areas for future work.
Original languageEnglish
Article number80
Number of pages12
JournalFrontiers in Endocrinology
Volume9
DOIs
Publication statusPublished - 12 Mar 2018

Keywords

  • Insulin-like growth factor binding protein
  • Teleost fish
  • Genome duplication
  • Physiology
  • Comparative biology
  • Gene family evolution

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