Influenza virus activation of the interferon system

M.J. Killip; E. Fodor; R.E. Randall

doi:10.1016/j.virusres.2015.02.003

Influenza virus activation of the interferon system

M.J. Killip, E. Fodor, R.E. Randall

Research output: Contribution to journal › Article › peer-review

Abstract

The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.

Original language	English
Journal	Virus Research
Early online date	9 Feb 2015
DOIs	https://doi.org/10.1016/j.virusres.2015.02.003
Publication status	Published - 2015

Keywords

Influenza viruses
Innate immunity
Interferon
RIG-I

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10.1016/j.virusres.2015.02.003

Killip_2015_VR_Influenza_CC
© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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title = "Influenza virus activation of the interferon system",

abstract = "The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.",

keywords = "Influenza viruses, Innate immunity, Interferon, RIG-I",

author = "M.J. Killip and E. Fodor and R.E. Randall",

note = "This study was supported by the Wellcome Trust (grant number 087751/A/08/Z) and the Medical Research Council (grant number G0700848).",

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AU - Killip, M.J.

AU - Fodor, E.

AU - Randall, R.E.

N1 - This study was supported by the Wellcome Trust (grant number 087751/A/08/Z) and the Medical Research Council (grant number G0700848).

PY - 2015

Y1 - 2015

N2 - The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.

AB - The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.

KW - Influenza viruses

KW - Innate immunity

KW - Interferon

KW - RIG-I

U2 - 10.1016/j.virusres.2015.02.003

DO - 10.1016/j.virusres.2015.02.003

M3 - Article

SN - 0168-1702

JO - Virus Research

JF - Virus Research

ER -

Influenza virus activation of the interferon system

Abstract

Keywords

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