Influenza virus activation of the interferon system

M.J. Killip, E. Fodor, R.E. Randall

Research output: Contribution to journalArticlepeer-review

144 Citations (Scopus)
3 Downloads (Pure)

Abstract

The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.
Original languageEnglish
JournalVirus Research
Early online date9 Feb 2015
DOIs
Publication statusPublished - 2015

Keywords

  • Influenza viruses
  • Innate immunity
  • Interferon
  • RIG-I

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