Abstract
Eight healthy adults were given single oral doses of ketoconazole (200, 400, 600, and 800 mg) in the fasting state and with a standard breakfast at weekly intervals according to a balanced block design. Concentrations in serum were measured up to 32 h after the dose. Food did not reduce ketoconazole absorption or significantly alter peak ketoconazole concentrations in serum, though there was a food-related delay in achieving peak concentrations. At the 400- and 600-mg doses, food appeared to enhance absorption, but this effect was not seen at the 800-mg dose. With an increase in dose, the half-life and area under the serum concentration-time curve increased disproportionately, suggesting that the pharmacokinetics of ketoconazole may be dose dependent. Up to the 800-mg dose, the elimination of ketoconazole did not appear to be saturable. Administration of the drug with food is unlikely to be a cause of therapeutic failure.
Original language | English |
---|---|
Pages (from-to) | 1-3 |
Number of pages | 3 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 25 |
Issue number | 1 |
Publication status | Published - Jan 1984 |
Keywords
- Adult
- Eating
- Fasting
- Female
- Half-Life
- Humans
- Ketoconazole/blood
- Kinetics
- Male