Inferring the chemical mechanism from structures of enzymes

James Henderson Naismith

doi:10.1039/b602313d

Inferring the chemical mechanism from structures of enzymes

James Henderson Naismith

Research output: Contribution to journal › Article › peer-review

Abstract

Chemistry has once again embraced the study of enzyme mechanism as a core discipline. Chemists are uniquely able to contribute to the analysis of enzymes through their understanding of the reactivity of atoms. In this tutorial review for the Corday-Morgan medal, I will concentrate on the work from my lab over the past six years. I discuss enzymes which transform carbohydrates and incorporate halogens. The tutorial review will emphasise the strengths and limitations of structural biology as a means to deducing the chemical mechanism.

Original language	English
Pages (from-to)	763-770
Number of pages	8
Journal	Chemical Society Reviews
Volume	35
Issue number	9
DOIs	https://doi.org/10.1039/b602313d
Publication status	Published - Sept 2006

Keywords

UDP-GALACTOSE 4-EPIMERASE
BIOSYNTHETIC GENE-CLUSTER
TRYPTOPHAN 7-HALOGENASE PRNA
DTDP-D-GLUCOSE
ESCHERICHIA-COLI
CRYSTAL-STRUCTURE
ACTIVE-SITE
KEY ENZYME
PSEUDOMONAS-FLUORESCENS
POLYMYXIN RESISTANCE

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10.1039/b602313d

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title = "Inferring the chemical mechanism from structures of enzymes",

abstract = "Chemistry has once again embraced the study of enzyme mechanism as a core discipline. Chemists are uniquely able to contribute to the analysis of enzymes through their understanding of the reactivity of atoms. In this tutorial review for the Corday-Morgan medal, I will concentrate on the work from my lab over the past six years. I discuss enzymes which transform carbohydrates and incorporate halogens. The tutorial review will emphasise the strengths and limitations of structural biology as a means to deducing the chemical mechanism.",

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year = "2006",

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doi = "10.1039/b602313d",

language = "English",

volume = "35",

pages = "763--770",

journal = "Chemical Society Reviews",

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KW - UDP-GALACTOSE 4-EPIMERASE

KW - BIOSYNTHETIC GENE-CLUSTER

KW - TRYPTOPHAN 7-HALOGENASE PRNA

KW - DTDP-D-GLUCOSE

KW - ESCHERICHIA-COLI

KW - CRYSTAL-STRUCTURE

KW - ACTIVE-SITE

KW - KEY ENZYME

KW - PSEUDOMONAS-FLUORESCENS

KW - POLYMYXIN RESISTANCE

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U2 - 10.1039/b602313d

DO - 10.1039/b602313d

M3 - Article

SN - 0306-0012

VL - 35

SP - 763

EP - 770

JO - Chemical Society Reviews

JF - Chemical Society Reviews

IS - 9

ER -

Inferring the chemical mechanism from structures of enzymes

Abstract

Keywords

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