Inferring the chemical mechanism from structures of enzymes

James Henderson Naismith

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Chemistry has once again embraced the study of enzyme mechanism as a core discipline. Chemists are uniquely able to contribute to the analysis of enzymes through their understanding of the reactivity of atoms. In this tutorial review for the Corday-Morgan medal, I will concentrate on the work from my lab over the past six years. I discuss enzymes which transform carbohydrates and incorporate halogens. The tutorial review will emphasise the strengths and limitations of structural biology as a means to deducing the chemical mechanism.

Original languageEnglish
Pages (from-to)763-770
Number of pages8
JournalChemical Society Reviews
Volume35
Issue number9
DOIs
Publication statusPublished - Sept 2006

Keywords

  • UDP-GALACTOSE 4-EPIMERASE
  • BIOSYNTHETIC GENE-CLUSTER
  • TRYPTOPHAN 7-HALOGENASE PRNA
  • DTDP-D-GLUCOSE
  • ESCHERICHIA-COLI
  • CRYSTAL-STRUCTURE
  • ACTIVE-SITE
  • KEY ENZYME
  • PSEUDOMONAS-FLUORESCENS
  • POLYMYXIN RESISTANCE

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