Induction of chiral porous solids containing only achiral building blocks

Russell E. Morris, Xianhui Bu

Research output: Contribution to journalReview articlepeer-review

500 Citations (Scopus)

Abstract

In many areas of chemistry the synthesis of chiral compounds is a target of increasing importance. They play a vital role in biological function and in many areas of society and science, including biology, medicine, biotechnology, chemistry and agriculture. Many pharmaceutical molecules, like their biological targets, are chiral and it is therefore easy to understand the growing demand for efficient methods of producing enantiomerically pure compounds. This is equally true for the preparation of chiral solids, which have potential applications in asymmetric catalysis, chiral separations and the like. In this Review we will consider recent progress and future potential in the development of methods for the preparation of chirally pure solids, in particular where the building blocks of the structure are achiral themselves. We will discuss strategies for the synthesis of both inorganic (for example, zeolites) and inorganic-organic hybrid (for example, metal organic framework) chiral porous solids.

Original languageEnglish
Pages (from-to)353-361
Number of pages9
JournalNature Chemistry
Volume2
Issue number5
DOIs
Publication statusPublished - May 2010

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